Antibiotics Versus Surgery in Acute Appendicitis — ASAA  

Acute Appendicitis Without Peritonitis Clinical Trial

Official title: Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study

Status Recruiting

Clinical Trial Summary

The acute appendicitis (AA) is a very common disease with a life time risk 7-8% and the highest incidence in the second decades . The aetiology of AA is still poor understood: the commonest hypothesis refers to appendix obstruction followed by impairment of wall appendix barrier and thus wall perforation and/or abscess formation1. However some studies suggest that no-complicate and complicate appendicitis are different entities allowing a different treatment. The study aims to test the no inferiority in terms of efficacy of antibiotic treatment compared to surgery in a population with high probability to suffer of 1st episode of AA.The study aims to test the no inferiority in terms of efficacy of antibiotic treatment compared to surgery in a population with high probability to suffer of 1st episode of AA.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Appendicitis Without Peritonitis
• Acute Disease
• Appendicitis
• Peritonitis

• NCT number: NCT01421901
• Study type: Interventional
• Source: A.O. Ospedale Papa Giovanni XXIII
• Contact: Michele Pisano, Principal investigator
• Phone: 0039 0352673412
• Email: mpisano@hpg23.it
• Status: Recruiting
• Phase: Phase 4
• Start date: August 2011
• Completion date: June 2015