Acidosis, Renal Tubular Clinical Trial
Official title:
Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients
The aim of this study was to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.
Hyperchloremic acidosis is frequent in critically ill patients. Renal tubular acidosis (RTA)
may contribute to acidemia in the state of hyperchloremic acidosis, but the prevalence of
RTA has never been studied in critically ill patients. Therefore, we aimed to investigate
the prevalence, type, and possible risk factors of RTA in critically ill patients using a
physical-chemical approach.
This prospective, observational trial was conducted in a medical ICU of a university
hospital. 100 consecutive critically ill patients at the age ≥18, expected to stay in the
ICU for ≥24h, with the clinical necessity for a urinary catheter and the absence of anuria
were included.
Base excess subset calculation based on a physical-chemical approach on the first seven days
after ICU admission was used to compare the effects of free water, chloride, albumin, and
unmeasured anions on the standard base excess. Calculation of the urine osmolal gap (UOG) −
as an approximate measure of the unmeasured urine cation ammonium − served as determinate
between renal and extra-renal bicarbonate loss in the state of hyperchloremic acidosis.
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Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01690039 -
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
|
||
| Withdrawn |
NCT03831152 -
Extension Study in Primary Distal Renal Tubular Acidosis
|
Phase 3 |