Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients

Acidosis, Renal Tubular Clinical Trial

Official title:

Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02392091
• Other study ID #: RTA01
• Status: Completed
• Phase: N/A
• First received: March 12, 2015
• Last updated: March 17, 2015
• Start date: April 2011
• Est. completion date: March 2012

Study information

• Verified date: March 2015
• Source: Medical University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Ethikkommission
• Study type: Observational

Clinical Trial Summary

The aim of this study was to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.

Description:

Hyperchloremic acidosis is frequent in critically ill patients. Renal tubular acidosis (RTA) may contribute to acidemia in the state of hyperchloremic acidosis, but the prevalence of RTA has never been studied in critically ill patients. Therefore, we aimed to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.

This prospective, observational trial was conducted in a medical ICU of a university hospital. 100 consecutive critically ill patients at the age ≥18, expected to stay in the ICU for ≥24h, with the clinical necessity for a urinary catheter and the absence of anuria were included.

Base excess subset calculation based on a physical-chemical approach on the first seven days after ICU admission was used to compare the effects of free water, chloride, albumin, and unmeasured anions on the standard base excess. Calculation of the urine osmolal gap (UOG) − as an approximate measure of the unmeasured urine cation ammonium − served as determinate between renal and extra-renal bicarbonate loss in the state of hyperchloremic acidosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: March 2012
• Est. primary completion date: October 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• admitted to the medical ICU of the Div. of Gastroenterology & Hepatology of the Medical University of vienna

• age =18

• expectancy to stay in the ICU =24hours

• clinical necessity for a urinary catheter

Exclusion Criteria:

• anuria

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acidosis
• Acidosis, Renal Tubular
• Critical Illness

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Vienna

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	renal-tubular acidosis	Diagnosis of renal-tubular acidosis in critically ill patients within 7 days after ICU admission.	up to 7 days after ICU admission	No