Acid-Base Imbalance Clinical Trial
Official title:
Changes in Acid-base Variables Induced by Acute Variations in Partial Pressure of Carbon Dioxide in Whole Blood and Isolated Plasma of Septic Critically Ill Patients and Healthy Volunteers: an In-vitro Study
Alterations of acid-base equilibrium are very common in critically ill patients and
understanding their pathophysiology can be important to improve clinical treatment.
The human organism is protected against acid-base disorders by several compensatory
mechanisms that minimize pH variations in case of blood variations in carbon dioxide content.
The aim of the present study is to quantify the buffer power, i.e. the capacity to limit pH
variations in response to carbon dioxide changes, in critically ill septic patients and
compare these results with data collected from healthy volunteers.
Alterations of acid-base equilibrium are very common in critically ill patients and
understanding their pathophysiology can be important to improve clinical treatment.
The human body is protected against acid-base disorders by several compensatory mechanisms
that minimize pH variations in response to acid-base derangements.
The present study focuses on the acute compensatory mechanisms of respiratory acid-base
derangements, i.e., respiratory acidosis and respiratory alkalosis. In this case the
non-carbonic buffers are constituted by albumin and phosphates in plasma, with the addition
of hemoglobin in whole blood.
Aim of the present in-vitro study is to measure the buffer power of non-carbonic weak acids
contained in whole blood and isolated plasma, assess the relative contribution of red blood
cells and plasma proteins and perform a comparison between septic patients and healthy
controls.
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