Agreement Between Venous and Arterial Blood Gas Measurements in the Intensive Care Unit

Acid-Base Balance Clinical Trial

— AVANTI  

Official title:

Agreement Between Venous and Arterial Blood Gas Measurements in the Intensive Care Unit

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00569634
• Other study ID #: 07H-821001
• Status: Completed
• Phase: N/A
• Start date: January 2008
• Est. completion date: July 2008

Study information

• Verified date: March 2021
• Source: Olive View-UCLA Education & Research Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the agreement between venous blood gas and arterial blood gas measurements in patients in the Intensive Care Unit.

Description:

Venous blood gas analysis may be an alternative to arterial blood gas analysis for acid-base status, reducing the need for frequent invasive arterial sampling. The objective of this study is to examine the agreement between ABG and VBG samples for all commonly used parameters (pH, pCO2 and bicarbonate) in a pathologically diverse ICU patient population, specifically analyzing multiple paired arterial and venous samples from each patient.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: July 2008
• Est. primary completion date: July 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult patients 18 years or older
• Admitted to the Intensive Care Unit (ICU)
• Determined by their treating clinicians to require both a central venous line and arterial line

Exclusion Criteria:

• None

Related Conditions & MeSH terms

• Acid-Base Balance

Intervention

Procedure:
• Venous blood gas analysis
When an ABG is deemed to be necessary as part of ICU management, a central venous sample will also be obtained with minimum delay (always < 2 minutes) between the samples. The samples will be analyzed by a blood gas analyzer as quickly as possible.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Olive View-UCLA Education & Research Institute

References & Publications (14)

Ak A, Ogun CO, Bayir A, Kayis SA, Koylu R. Prediction of arterial blood gas values from venous blood gas values in patients with acute exacerbation of chronic obstructive pulmonary disease. Tohoku J Exp Med. 2006 Dec;210(4):285-90. — View Citation

Brandenburg MA, Dire DJ. Comparison of arterial and venous blood gas values in the initial emergency department evaluation of patients with diabetic ketoacidosis. Ann Emerg Med. 1998 Apr;31(4):459-65. — View Citation

Chu YC, Chen CZ, Lee CH, Chen CW, Chang HY, Hsiue TR. Prediction of arterial blood gas values from venous blood gas values in patients with acute respiratory failure receiving mechanical ventilation. J Formos Med Assoc. 2003 Aug;102(8):539-43. — View Citation

Criscuolo C, Nepper G, Buchalter S. Reflex sympathetic dystrophy following arterial blood gas sampling in the intensive care setting. Chest. 1995 Aug;108(2):578-80. Review. — View Citation

Gokel Y, Paydas S, Koseoglu Z, Alparslan N, Seydaoglu G. Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients with uremic acidosis and diabetic ketoacidosis in the emergency room. Am J Nephrol. 2000 Jul-Aug;20(4):319-23. — View Citation

Kelly AM, Kyle E, McAlpine R. Venous pCO(2) and pH can be used to screen for significant hypercarbia in emergency patients with acute respiratory disease. J Emerg Med. 2002 Jan;22(1):15-9. — View Citation

Kelly AM, McAlpine R, Kyle E. Agreement between bicarbonate measured on arterial and venous blood gases. Emerg Med Australas. 2004 Oct-Dec;16(5-6):407-9. — View Citation

Kelly AM, McAlpine R, Kyle E. Venous pH can safely replace arterial pH in the initial evaluation of patients in the emergency department. Emerg Med J. 2001 Sep;18(5):340-2. — View Citation

Ma OJ, Rush MD, Godfrey MM, Gaddis G. Arterial blood gas results rarely influence emergency physician management of patients with suspected diabetic ketoacidosis. Acad Emerg Med. 2003 Aug;10(8):836-41. — View Citation

Malatesha G, Singh NK, Bharija A, Rehani B, Goel A. Comparison of arterial and venous pH, bicarbonate, PCO2 and PO2 in initial emergency department assessment. Emerg Med J. 2007 Aug;24(8):569-71. — View Citation

Malinoski DJ, Todd SR, Slone S, Mullins RJ, Schreiber MA. Correlation of central venous and arterial blood gas measurements in mechanically ventilated trauma patients. Arch Surg. 2005 Nov;140(11):1122-5. — View Citation

Middleton P, Kelly AM, Brown J, Robertson M. Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate. Emerg Med J. 2006 Aug;23(8):622-4. — View Citation

Mortensen JD. Clinical sequelae from arterial needle puncture, cannulation, and incision. Circulation. 1967 Jun;35(6):1118-23. — View Citation

Rang LC, Murray HE, Wells GA, Macgougan CK. Can peripheral venous blood gases replace arterial blood gases in emergency department patients? CJEM. 2002 Jan;4(1):7-15. — View Citation

* Note: There are 14 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Agreement between venous and arterial blood gas measurements of pH, pCO2 and bicarbonate		Duration of Intensive Care Unit Admission