Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

Accident Caused by Snow Avalanche Clinical Trial

Official title:

Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04835545
• Other study ID #: DP-2021-Nemec
• Status: Active, not recruiting
• Phase: N/A
• Start date: March 29, 2021
• Est. completion date: April 1, 2024

Study information

• Verified date: July 2022
• Source: Czech Technical University in Prague
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Description:

The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 13
• Est. completion date: April 1, 2024
• Est. primary completion date: April 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I

• without a smoking history

Exclusion Criteria:

• Tiffeneau Index less than 0.70

• any cardiovascular or respiratory condition

Related Conditions & MeSH terms

• Accident Caused by Snow Avalanche
• Hypercapnia
• Respiratory Aspiration

Intervention

Other:
• extreme hypercapnia induced by ventilation insufficiency
extreme hypercapnia

Locations

Country	Name	City	State
Czechia	Czech Technical University, Faculty of Biomedical Engineering	Kladno

Sponsors (1)

Lead Sponsor	Collaborator
Czech Technical University in Prague

Country where clinical trial is conducted

Czechia, 

References & Publications (1)

Roubík K, Sieger L, Sykora K. Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study. PLoS One. 2015 Dec 14;10(12):e0144332. doi: 10.1371/journal.pone.0144332. eCollection 2015. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The length of breathing	Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.	Continuously within up to 7 minute interval from the beginning of the breathing experiment