Polycystic Ovary Syndrome Clinical Trial
OBJECTIVES: I. Evaluate insulin resistance in thin and obese hyperandrogenic women with
polycystic ovarian disease or hyperandrogenism insulin resistance acanthosis nigricans
syndrome and in thin and obese controls, using an estimation of tissue sensitivity to
insulin.
II. Evaluate the effect of androgen suppression with leuprolide acetate and spironolactone
on insulin secretion and resistance.
PROTOCOL OUTLINE: Participants are treated with subcutaneous leuprolide acetate followed by
oral spironolactone. Each treatment is administered daily for 6 weeks, with a 6-week washout
between drugs.
Patients and controls are alternately assigned to begin treatment with leuprolide acetate or
spironolactone.
;
Primary Purpose: Treatment
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