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Acanthosis Nigricans clinical trials

View clinical trials related to Acanthosis Nigricans.

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NCT ID: NCT02604095 Completed - Obesity Clinical Trials

Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism

Start date: May 2014
Phase: N/A
Study type: Interventional

Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism.

NCT ID: NCT02438020 Not yet recruiting - Clinical trials for Acanthosis Nigricans

Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity

Start date: June 2015
Phase: Phase 4
Study type: Interventional

Obesity is often accompanied by insulin resistance and/or hyperinsulinemia. Acanthosis nigricans (AN) is a skin condition commonly present on the neck of obese children. Metformin is a useful drug for conditions characterized by insulin resistance.The aim of this study is to compare the efficacy of metformin versus placebo on AN lesions of the neck as well as their effects on metabolic and anthropometric variables in a sample of obese children. This is a 12-week randomized, double-blind randomized trial involving obese children with AN to receive either metformin or placebo. Evaluations will be performed every three weeks. Clinical, histological and colorimetric assessments of AN lesions will be compared initially and at the conclusion of the study.

NCT ID: NCT01125150 Completed - Hyperinsulinemia Clinical Trials

Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia

Start date: February 2009
Phase: N/A
Study type: Observational

Acanthosis Nigricans is skin disease that associated with hyperinsulinemia. Clinical is velvety hyperpigmented plaques on neck, axilla, groin. If hyperinsulinemia is improved by treated with oral metformin and/ or diet control, acanthosis nigricans would be improved as well. Hyperpigmented plaques will be changed. We assess objective measurement by using spectroscopic and colorimetric analysis.

NCT ID: NCT00004311 Completed - Clinical trials for Polycystic Ovary Syndrome

Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome

Start date: July 1989
Phase: Phase 2
Study type: Interventional

OBJECTIVES: I. Evaluate insulin resistance in thin and obese hyperandrogenic women with polycystic ovarian disease or hyperandrogenism insulin resistance acanthosis nigricans syndrome and in thin and obese controls, using an estimation of tissue sensitivity to insulin. II. Evaluate the effect of androgen suppression with leuprolide acetate and spironolactone on insulin secretion and resistance.

NCT ID: NCT00000112 Recruiting - Obesity Clinical Trials

Prevalence of Carbohydrate Intolerance in Lean and Obese Children

Start date: n/a
Phase: N/A
Study type: Observational

The prevalence of obesity in children is reaching epidemic proportions. Excess adiposity is more than just a cosmetic problem, having substantial metabolic consequences. Insulin resistance, hyperinsulinemia, impaired glucose tolerance, and frank diabetes are often seen in obese children. In this study the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and obese children with acanthosis nigricans with or without a family history of diabetes mellitus will be studied.