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Absorption; Chemicals clinical trials

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NCT ID: NCT04355286 Completed - Sunscreening Agents Clinical Trials

Bemotrizinol UV Filter Part 1 Clinical PK Evaluation in Topical MUsT Study

BEMT
Start date: November 3, 2020
Phase: Phase 1
Study type: Interventional

This will be a single clinical study conducted in 2 parts (Part 1: pilot study and Part 2: pivotal study). Part 1 is an open-label, 1-arm study in 14 healthy adult subjects with the following primary objectives: - Primary: To explore whether the active component, bemotrizinol (BEMT), is absorbed from a high-penetrating sunscreen formulation including 6% BEMT into the systemic circulation when applied under maximal-use conditions. - Secondary: To obtain information needed for a successful pivotal study such as preliminary pharmacokinetic (PK) data, validation of study and analytical procedures, and the number of subjects needed. Part 2 is an open-label, randomized, 3-arm study in 42 healthy adult subjects with the following objective: • Primary: To assess the systemic absorption and pharmacokinetics of BEMT from 3 market image sunscreen formulations under maximal-use conditions.

NCT ID: NCT04078646 Recruiting - Metabolism Clinical Trials

Influence of Proteins on the Bioavailability of Carotenoids

CAROPROT
Start date: October 11, 2019
Phase: N/A
Study type: Interventional

A postprandial intervention study is conducted on healthy male subjects to evaluate whether the addition of proteins (why protein isolate, soy protein) can help to increase the bioavailability of carotenoids from a tomato/carrot beverage.

NCT ID: NCT03807050 Completed - Clinical trials for Absorption; Chemicals

Safety and Pharmacokinetics of Phaffia Rhodozyma Astaxanthin

Start date: November 19, 2018
Phase: N/A
Study type: Interventional

Astaxanthin is a xanthophyll carotenoid, a naturally occurring lipid-soluble red pigment. Apart from its coloring ability it is also a strong antioxidative ingredient and contains health-promoting properties. Study aim is to monitor the safety and tolerability of AstaFerm™, an astaxanthin dietary supplement derived from the yeast Phaffia rhodozyma. Pharmacokinetics profile is tested in 12 healthy male adults who received a single dose of AstaFerm™ in a single-center, open-label, non-randomized, single-dose study. Subjects are admitted to the clinical research center on the evening before dosing. On the next morning, after overnight fast, pre-dosing plasma sampling is performed, then they receive a fat balanced breakfast followed by a single administration of AstaFerm™ capsules. The capsules contain 50 milligram astaxanthin derived from Phaffia rhodozyma. Following dosing, blood sampling is performed for 24 hours in-house (2, 4, 6, 8, 10, 12 and 24-hours post-dose) and ambulatory at 48, 72- and 168-hours post-dose. Blood for antioxidant activity assessment is also drawn.

NCT ID: NCT03433040 Active, not recruiting - Premature Birth Clinical Trials

17OHP-C Dosing Among Obese Pregnant Women

Start date: August 23, 2017
Phase: Phase 3
Study type: Interventional

Emergency data suggest 17OHP-C may be less efficacious in obese women. Since obesity is associated with lower levels of plasma 17OHP-C, the investigator hypothesize that higher doses of 17OHP-C may help to prevent spontaneous PTB among obese women. The study aims to compare the pharmacokinetics of 17 OHP-C in obese compared with non-obese women.

NCT ID: NCT02227615 Active, not recruiting - Clinical trials for Absorption; Chemicals

Absorption of Mango in Healthy Individuals

Start date: March 2013
Phase: N/A
Study type: Interventional

The objective of this research is to characterize the urinary metabolites produced after the consumption of mango pulp in an effort to begin to characterize the bioavailability of the major group of polyphenolics in mango, ester-linked gallic acids, and to provide new insight into their in vivo physiological behavior.