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Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk

Abortion, Spontaneous Clinical Trial

Official title:
Association Between Interleukin-10 Promoter-1082A/G Polymorphism With Idiopathic Recurrent Miscarriage Risk of Chinese Han

Clinical Trial Summary

This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han. A total of 100 women with IRM and 100 control women with a successful pregnancy will be included in this study. Then genotyping will be performed.

Clinical Trial Description

As a common occurrence in early pregnancy, IRM has been associated with multiple causes, among which the disorders of immune homeostasis between the fetus and the maternal immune system, maintained by cytokines from the complex regulatory network, are considered one of the potential etiological factors underlying IRM.

The IL-10 polymorphism -1082A/G (rs1800896), which is located in the promoter region of the IL-10 gene, was reported to be implicated in the abnormal expression of IL-10 in IRM by some studies.

However, no such reports about the association between IL-10 polymorphism -1082A/G and IRM risk in Chinese Han. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02633475
Study type Observational
Source Fourth Affiliated Hospital of Guangxi Medical University
Contact Zheng Peng
Phone +86 18589966550
Email labstar@qq.com
Status Recruiting
Phase N/A
Start date August 2015
Completion date December 2017
View Details
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