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Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia — MetRPL  

Abortion, Habitual Clinical Trial

Official title:
Phase 4 Study of Effectiveness of Metformin in Patients With Unexplained Recurrent Miscarriages

Clinical Trial Summary

The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but also pathognomic for various obstetrical complications during pregnancy.An elevated free androgen index appears to be a prognostic factor for a subsequent miscarriage in women with recurrent miscarriage. There is insufficient evidence to evaluate the effect of metformin supplementation in pregnancy to prevent a miscarriage in women with recurrent miscarriage.

Clinical Trial Description

The patients with PCO and hyper insulinemia will be subdivided into two groups, one group will continue metformin 500 mg three times per day from the start of induction of ovulation till the end of pregnancy, the other group will stop the drug once pregnancy test become positive. Pregnancy follow up including the early and second trimester pregnancy loss, Secondary outcomes like gestational diabetes, pregnancy-induced hypertension and intrauterine growth restriction were also analyzed at the end of the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01718340
Study type Interventional
Source Woman's Health University Hospital, Egypt
Contact
Status Withdrawn
Phase Phase 4
Start date June 2012
Completion date June 2014
View Details
See also
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