Abnormal Uterine Bleeding Unrelated to Menstrual Cycle Clinical Trial
Official title:
Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding (AUB) Using Sublingual Misoprostol 200 Mcg: A Randomized, Double Blind, Placebo-controlled Trial
Abnormal uterine bleeding is common in Thai women. Fractional curettage is an diagnostic
procedure of this condition. Traditionally, fractional curettage is performed under local
anesthesia such as paracervical nerve block or intravenous meperidine.
Cervical dilatation using "metal cervical dilator" is a common method prior to perform
fractional curettage. However, complication from this procedure can be occurred frequently,
for example, uterine perforation, false tract formation and laceration of cervix.
Misoprostol is a prostaglandin E1 analogue which is commonly used in obstetrics and
gynecology. Misoprostol transforms cervical component causing cervical ripening. This is
very helpful for transcervical procedure because cervical dilatation is usually omitted. It
can be prescribed in many route and sublingual route is the most effectiveness. Moreover,
WHO supports the use of misoprostol in obstetrics and gynecology practice.
The hypothesis of this study is that "Misoprostol 200 micrograms sublingually is effective
for cervical ripening before performing fractional curettage in patients with abnormal
uterine bleeding" Double blind randomised controlled trial was performed using 26 patients
in each group.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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