Atrial Fibrillation Clinical Trial
Official title:
Ablating Atrial Tachycardias Occuring During Ablation of Complex Fractionated Electrograms in Persistent AF - ATTAC CFAE Trial
Catheter ablation has proven to be an effective treatment option in patients suffering from
symptomatic persistent atrial fibrillation (AF). Catheter ablation consists of two major
steps: (1) Isolation of pulmonary veins to abolish the trigger of atrial fibrillation and
(2) modification of left atrial and eventually right atrial substrate by ablation of complex
fractionated atrial electrograms (CFAE). CFAE are mainly found at the ostia of the pulmonary
veins, around the left atrial appendage, at the mitral annulus and the septum.
When ablating CFAE 40-65% of the patients show a regularization of AF to an atrial
tachycardia (AT) that can be macro- or micro-reentrant (localized re-entry). Until now the
significance of the AT is unclear.
In the following study we examine the hypothesis that an ablation of AT occuring during CFAE
ablation (group 1) significantly improves outcome defined as freedom of atrial arrhythmia
(AF or AT) compared to patients that are cardioverted when AF has regularized to AT (group
2).
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