Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06265948 |
| Other study ID # |
comparsion drugs in cancer |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 2024 |
| Est. completion date |
May 2025 |
Study information
| Verified date |
February 2024 |
| Source |
Assiut University |
| Contact |
khaled Hussien |
| Phone |
01029314432 |
| Email |
kh1357kha[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
( post operative pain between intravenous infusion ketofol and standard inhalational general
anesthesia in abdominal cancer surgeries )
Description:
ketofol, which is a combination of ketamine and propofol, has been increasingly used because
the advantages and disadvantages of propofol and ketamine complement each other and increase
their effectiveness. Recently, the use of a combination of ketamine and propofol (ketofol) as
a sedative has been attracting attention in various clinical fields. Theoretically, the
combination of ketamine and propofol can reduce the dose of each drug and compensate for the
disadvantages of the other through the antagonistic characteristics of both drugs, resulting
in beneficial results for successful sedation
. Most of the time propofol and ketamine have been used as an induction agent in adult
surgical patients but propofol may cause cardiorespiratory depression while ketamine
increases heart rate and arterial blood pressure. On the other hand, the clinical effects of
propofol and ketamine seem to be complementary. Ketofol is most commonly used for procedural
sedation hence exploring its effectiveness for induction will be paramount for the clinical
care of surgical patients Inhalation anesthetics (nitrous oxide, halothane, isoflurane,
desflurane, sevoflurane, most commonly used agents in practice today) are used for induction
and maintenance of general anesthesia in the operating room. The volatile anesthetics
(halothane, isoflurane, desflurane, and sevoflurane) are liquids at room temperature and
require the use of vaporizers for inhalational administration. Nitrous Oxide is already under
normal conditions of temperature and pressure. All inhalational anesthetics provide amnesia
and immobility, except for nitrous oxide, which also provides analgesia. Inhaled anesthetics
are commonly used in combination with IV anesthetic agents. These agents have FDA approval
for use as a general anesthetic and sedation agent in the operating room. Inhaled anesthetic
agents have also had use in the intensive care unit, but this is not an FDA-approved
indication. The primary applications of inhaled anesthetic agents in the ICU are sedation,
refractory bronchospasm, and control of status epilepticus unresponsive to anticonvulsant
medications.
