The Analgesic Efficacy of Ultrasound Guided Transversus Abdominal Plane

Status Completed

Clinical Trial Summary

Effective postoperative pain control results in decreased cardiac and pulmonary complications, patient satisfaction and early mobilization. A prospective, randomized comparative study was done of analgesic efficacy, opioid requirement and side effects in patients undergoing lower abdominal cancer surgeries. In Study Group Ultrasound guided Transversus Abdominis Plane (TAP) block was given and control Group no TAP block was given. Patient controlled analgesia (PCA) with intravenous morphine was given to both group patients, and total good PCA demands in both the groups was studied.

Clinical Trial Description

Adult patients of both sexes undergoing major lower abdominal cancer surgeries were enrolled in the study. After obtaining written informed consent from all the patients, they were randomly allotted to either Study (TAP) Group or Control group. Standard general anesthesia with endotracheal intubation was performed in all the patients. Preoperatively all patients received information about Visual Analogue Scale (VAS) for Pain Score from 1 to 10 depending on intensity of pain and about the use of Patient Controlled Analgesia (PCA) Pump. After the end of surgery and before extubation bilateral Ultrasound guided Transversus Abdominis Plane (TAP) block was performed with 16 G Tuohy needle and 18 G Braun Perifix epidural catheter was placed about 6-8 cms in situ. Bupivacaine 0.25 % 20 ml was given bilaterally and repeated 8 hourly in the Postoperative Anaesthesia Care Unit (PACU) for first 24 hours. The PCA Pump was set to deliver bolus Intravenous Morphine 1 milligram ( mg ) with lock out interval 10 minutes. In the PACU heart rate, Non invasive blood pressure, Visual Analogue Score at rest and on knee flexion, Sedation score, nausea and vomiting, any side effects as itching was noted by care provider at 0, 2, 4, 6, 12, 18 and 24 hours. Total and good PCA demands upto 24 hours was recorded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03165383
Study type	Interventional
Source	Rajiv Gandhi Cancer Institute & Research Center, India
Contact
Status	Completed
Phase	N/A
Start date	February 11, 2013
Completion date	August 20, 2014

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03144622` - 18F-FSPG PET/CT Imaging in Patients With Cancers
Completed	`NCT04553471` - Palliative Lattice Stereotactic Body Radiotherapy (SBRT) for Patients With Sarcoma, Thoracic, Abdominal, and Pelvic Cancers	N/A
Completed	`NCT02566096` - Efficacy of Transverses Abdominis -Plane Block With Bupivacaine Versus Bupivacaine With Morphine Postoperatively	Phase 4
Recruiting	`NCT05533424` - Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block as Postoperative Analgesia in Patients Undergoing Abdominal Cancer Surgery.	Phase 3
Completed	`NCT04729634` - Survey Of Mobilisation and Breathing Exercises After Thoracic and Abdominal Surgery	N/A
Recruiting	`NCT00493688` - A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
Completed	`NCT04152564` - Cardio-pulmonary and Analgesic Effects of Pre-peritoneal VS Epidural Infusion of L-bupivacaine on Abd. Cancer Patients	N/A
Completed	`NCT03555266` - NSS-2 BRIDGE Device in Post-Operative Pain Management	N/A
Withdrawn	`NCT04114422` - A Seven-day Preoperative Exercise Training Program in People With Abdominal Cancer	N/A
Terminated	`NCT04199754` - IV Contrast-Enhanced Cone Beam Computed Tomography (CBCT) in Radiotherapy	Early Phase 1
Recruiting	`NCT03063112` - Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain	N/A
Completed	`NCT02998736` - Trial of Perioperative Tadalafil and Influenza Vaccination in Cancer Patients Undergoing Major Surgical Resection of a Primary Abdominal Malignancy	Phase 1
Completed	`NCT00780611` - Investigating the Improvement in 4D CT Images Using AV Biofeedback
Completed	`NCT00415675` - Respiratory Tumor and Normal Tissue Motion	N/A
Not yet recruiting	`NCT05903430` - A Feasibility Study of MRI Guided Stereotactic Ablative Radiotherapy (MIDSECTION)
Completed	`NCT03751384` - Improvement of Compliance for High Doses of EPA Amongst Patients With Colorectal Cancer	N/A
Recruiting	`NCT05219058` - Reconstruction in Extended MArgin Cancer Surgery
Completed	`NCT03102619` - Wireless Assessment of Respiratory and Circulatory Distress; A Pilot Study	N/A
Not yet recruiting	`NCT06265948` - Comparsion Between Intravenous Infusion of Ketofol and Inhalational Anasthetics in Abdominal Cancer Surgeries for Post Operative Analgesia
Completed	`NCT05524454` - Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Analgesic Efficacy of Ultrasound Guided Transversus Abdominal Plane Block After Abdominal Cancer Surgeries — TAP

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms