Contrast Enhanced Ultrasound, Endoleak Detection Following EVAR v1.3

Status Completed

Clinical Trial Summary

A single site cross-sectional comparison of paired diagnostic imaging modalities. This study will show the sensitivity and specificity of CEUS in detecting the various types of endoleaks, in comparison to tCTA, following EVAR. It will collect data to allow comparison of diagnostic accuracy across modalities including CDU, CEUS and tCTA. It will collect time taken to perform the various types of scan, to allow healthcare costs to be calculated for each imaging modality.

Clinical Trial Description

This study will show the sensitivity and specificity of CEUS in detecting the various types of endoleaks, in comparison to tCTA, following EVAR. It will collect data to allow comparison of diagnostic accuracy across modalities including CDU, CEUS and tCTA. It will collect time taken to perform the various types of scan, to allow healthcare costs to be calculated for each imaging modality. Collected data will be analysed regarding two novel hypothesised methods of using CEUS information: The first is recording temporal delay between contrast in graft and contrast in endoleak to define endoleak type. Potentially this could be used as a faster method of defining endoleak type in a surveillance programme. The second is to identify/refute correlation between CEUS contrast to appear in endoleak vs tCTA contrast to appear in endoleak. If an association can be established, CEUS timings could potentially then be used to time 'standard' CTA phases to improve CTAs diagnostic accuracy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02688751
Study type	Observational
Source	Liverpool University Hospitals NHS Foundation Trust
Contact
Status	Completed
Phase
Start date	January 20, 2016
Completion date	March 20, 2018

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04227054` - Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks	N/A
Active, not recruiting	`NCT03687489` - Safety and Efficacy Study of Abdominal Aortic Aneurysm Stent Graft System	N/A
Active, not recruiting	`NCT03507413` - Metformin Therapy in Non-diabetic AAA Patients	Phase 2/Phase 3
Not yet recruiting	`NCT05756283` - The PREHAAAB Trial: Multimodal Prehabilitation for Patients Awaiting Open Abdominal Aortic Aneurysm Repair	N/A
Not yet recruiting	`NCT04089241` - Fusion of CT Angiography With 3D Contrast Ultrasound as a Method for Follow up for Endovascular Aneurysm Repair	N/A
Active, not recruiting	`NCT02604303` - A Prospective Analysis on the Expansion Rates of Abdominal Aortic Aneurysms
Terminated	`NCT02469376` - Evaluation of a New Imagingtechnologie for Thrombosis	Phase 1
Completed	`NCT02224794` - LIFE Study: Least Invasive Fast-Track EVAR
Terminated	`NCT01843335` - Contrast-enhanced Ultrasound in Follow-up After Endovascular Aneurysm Repair	N/A
Completed	`NCT02229006` - Sodium Fluoride Imaging of Abdominal Aortic Aneurysms	N/A
Completed	`NCT01118520` - AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK)	Phase 2
Terminated	`NCT01425242` - Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension	N/A
Completed	`NCT00746122` - Immediate Management of the Patient With Rupture : Open Versus Endovascular Repair	N/A
Completed	`NCT03952780` - Korean Registry of Percutaneous EVAR With INCRAFT Stent Graft for the Treatment of Abdominalaortic Aneurysm (K-INCRAFT)
Completed	`NCT00583414` - Endovascular Exclusion of Abdominal Aortic Aneurysms in High Risk Patients	N/A
Recruiting	`NCT05864560` - Ankura™ AAA, Cuff and AUI Stent Graft System Post-Market Clinical Follow-Up
Completed	`NCT01683084` - Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms	Phase 4
Active, not recruiting	`NCT03180996` - Global Fenestrated Anaconda Clinical sTudy
Completed	`NCT02493296` - The Effect of Surgery on Central Aortic Pressure & haEmodynamics Study
Completed	`NCT03320408` - Predicting Aneurysm Growth and Rupture With Longitudinal Biomarkers