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Clinical Trial Summary

The goal of this study is to collect preliminary data on the efficacy of a cognitive remediation program in improving the neurocognitive deficits in children with chromosome 22q11.2 deletion syndrome (22q11DS). This study involves a two part approaching including a computerized cognitive remediation program (CCRP, Posit Science, CA) in combination with a Social Cognitive Training (SCT) program. The computer-based training program has shown encouraging results in improving learning deficits in individuals with schizophrenia and we now seek to adapt them to children with 22q11DS, who have unique needs due to their lower IQ and high risk of psychosis in late adolescence and adulthood. The SCT is a small-group intervention program based on cognitive enhancement therapy, which has been shown to improve social cognition and functionality in adults with schizophrenia. A preliminary study will be performed using this two-pronged approach, to establish the feasibility and gather preliminary data on neurocognition before and after the intervention in these children; these data would enable a larger randomized controlled study to assess the efficacy of this approach.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label


Related Conditions & MeSH terms


NCT number NCT01781923
Study type Interventional
Source Duke University
Contact
Status Completed
Phase N/A
Start date October 2010
Completion date June 2015

See also
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Terminated NCT03284060 - Social Cognition Training and Cognitive Remediation N/A
Completed NCT02895906 - Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Phase 1
Recruiting NCT04639388 - Understanding of Psychotic Disorders in Children With 22q11.2DS N/A
Completed NCT00916955 - Genetic Modifiers for 22q11.2 Syndrome
Recruiting NCT05924347 - Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development
Recruiting NCT00556530 - Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
Completed NCT02460328 - Resolution of Primary Immune Defect in 22q11.2 Deletion Syndrome N/A
Completed NCT04647500 - Effects of Methylphenidate on Brain and Cognition in 22q11 Deletion Syndrome N/A