| Eligibility |
Inclusion Criteria:
- Adult male or female between 18 and 50 years of age, inclusive.
- Good general health as determined by physical examination, laboratory screening, and
review of medical history.
- Available for the duration of the study, which is approximately 26 weeks.
- Willingness to participate in the study as evidenced by signing the informed consent
document.
- Females only: Female subjects of childbearing potential, with the exception noted
below, should be willing to use effective contraception and have no plans to undergo
IVF (in vitro fertilization) during participation in the trial. Reliable methods of
contraception include hormonal birth control, condoms with spermicide, diaphragm with
spermicide, surgical sterilization, and intrauterine device. Women must have been on
an effective method of birth control for at least 30 days prior to enrollment. All
female subjects will be considered as having childbearing potential, except for women
who exclusively have sex with women, those who have had a hysterectomy, tubal
ligation, or tubal coil (at least 3 months prior to vaccination), or are considered to
be post-menopausal, as documented by at least 1 year since last menstrual period with
a follicle-stimulating hormone (FSH) level in the menopausal range or at least 24
consecutive months of amenorrhea. Transgender men who have internal female organs and
have sex with men will be considered of childbearing potential and should be willing
to use effective contraception during the trial. Exception: Females who have sex with
females (exclusively) and have no intention of conceiving a child during the study and
women whose partners have had a vasectomy will not be required to use contraception,
however they will be required to use female condoms and/or dental dams for at least 1
month following vaccination. For women whose sexual partner has had a vasectomy, the
vasectomy must have been performed 30 days or more prior to enrollment.
- Males only: Males of reproductive potential should be willing to use barrier
contraception for the first 3 months following vaccination* and agree to not donate
sperm for the duration of the study.
- Based on CDC guidance for men returning from ZIKV-endemic areas
Exclusion Criteria:
- Females only: Currently pregnant, as determined by positive ß-human choriogonadotropin
(HCG) test, or breast-feeding.
- Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic,
rheumatologic, autoimmune, or renal disease based on history, physical examination,
and/or laboratory studies.
- Behavioral, cognitive, or psychiatric disease that, in the opinion of the
investigator, affects the subject's ability to understand and cooperate with the
requirements of the study protocol.
- Screening laboratory values of Grade 1 or above for absolute neutrophil count (ANC),
alanine aminotransferase (ALT), and serum creatinine, as defined in this protocol.
- Any other condition that, in the opinion of the investigator, would jeopardize the
safety or rights of a subject participating in the trial, or would render the subject
unable to comply with the protocol.
- Any significant alcohol or drug abuse in the past 12 months that has caused medical,
occupational, or family problems, as indicated by subject history.
- History of a severe allergic reaction or anaphylaxis.
- Severe asthma (emergency room visit or hospitalization within the last 6 months).
- HIV infection, as indicated by screening and confirmatory assays.
- Hepatitis C virus (HCV) infection, as indicated by screening and confirmatory assays.
- Hepatitis B virus (HBV) infection, as indicated by hepatitis B surface antigen (HBsAg)
screening.
- Any known immunodeficiency syndrome.
- History of Guillain-Barrè syndrome.
- Current use of anticoagulant medications (this does not include anti-platelet
medication such as aspirin or non-steroidal anti-inflammatory medications).
- Use of immunosuppressive corticosteroids (excluding topical or nasal) or
immunosuppressive drugs within 28 days prior to or following inoculation. An
immunosuppressive dose of corticosteroids is defined as greater than or equal to 10 mg
of a prednisone equivalent per day for greater than or equal to 14 days.
- Receipt of a live vaccine within 28 days or a killed vaccine within 14 days prior to
inoculation, or anticipated receipt of any vaccine during the 28 days following
inoculation with the exception of COVID-19 vaccines either licensed or under EUA which
can be given at any time, however all effort will be made to avoid giving COVID-19
vaccines within the above windows.
- Asplenia.
- Receipt of blood products within the past 6 months, including transfusions or
immunoglobulin, or anticipated receipt of any blood products or immunoglobulin during
the 28 days following inoculation.
- History or serologic evidence of previous ZIKV or other flavivirus infection (e.g.,
dengue, yellow fever virus, St. Louis Encephalitis virus, or West Nile virus).
- Previous receipt of a flavivirus vaccine (licensed or experimental).
- Receipt or anticipated receipt of any investigational agent in the 28 days before or
after inoculation with the exception of COVID-19 vaccines, either licensed or
authorized under EUA.
- Refusal to allow specimen storage for future research.
- Is in isolation or quarantine for SARS-CoV-2 infection or exposure and cannot complete
screening or enrollment for this reason.
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