Clinical Trials Logo

Clinical Trial Summary

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of 12 months to observe the presence, viral load and infectivity of Zika virus (ZIKV) in semen over time.


Clinical Trial Description

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of 12 months to observe the presence, viral load and infectivity of Zika virus (ZIKV) in semen over time.

Knowledge of the possible presence, infectivity and persistence of ZIKV in semen will provide evidence-based data for

1. estimating of the risk of sexual transmission of ZIKV in the general population

2. antenatal guidelines for the prevention of sexual transmission of ZIKV to the fetus

3. advising couples on the length of time that pregnancy should be avoided in women wishing to conceive after their partner's ZIKV infection

4. strategies to prevent transmission of ZIKV infection through assisted reproductive treatment (ART)

5. advice on gamete cryopreservation

6. optimising investigations for diagnosis of ZIKV in males. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02979938
Study type Observational
Source Trinidad and Tobago IVF and Fertility Centre
Contact
Status Completed
Phase
Start date July 2016
Completion date August 2017

See also
  Status Clinical Trial Phase
Recruiting NCT03188731 - ZIKAlliance Pregnant Women Cohort N/A
Recruiting NCT03110770 - VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Phase 2
Active, not recruiting NCT02733796 - Persistence of Zika Virus in Semen After Acute Infection
Recruiting NCT02794181 - Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)
Recruiting NCT01099852 - Cohort of Patients Infected by an Arbovirus N/A
Recruiting NCT03611946 - Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Phase 1
Recruiting NCT03106714 - Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil
Recruiting NCT03227601 - Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome N/A
Not yet recruiting NCT03204409 - ZIKAlliance Natural History Study N/A
Recruiting NCT03393286 - ZIKAlliance Children Cohort (ZIKAllianceCH) N/A
Completed NCT03425149 - Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Phase 1
Active, not recruiting NCT03014089 - Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Phase 1
Recruiting NCT03263195 - Prospective Cohort Study of HIV and Zika in Infants and Pregnancy
Completed NCT02996890 - Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Phase 1