Ventilator Associated Pneumonia Clinical Trial
Official title:
Effect of Nasal and Oropharyngeal Use of Povidone Iodine and Glycyrrhizin on Ventilator-associated Respiratory Infections: A Randomized Trial
Verified date | November 2023 |
Source | Menoufia University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It has been shown that oral hygiene reduces the incidence of ventilator-associated pneumonia (VAP). The nasopharynx is considered to be an important source of contaminated micro aspiration to the lung however, the effect of nasopharyngeal decontamination on VAP has not been yet investigated. The investigators hypothesized that decontamination of oral and nasopharyngeal cavities with combined Povidone Iodine and glycyrrhizin would remarkably reduce the incidence of VAP.
Status | Completed |
Enrollment | 78 |
Est. completion date | November 24, 2023 |
Est. primary completion date | November 24, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - on mechanical ventilation less than 24 h after admission and expected to continue mechanical ventilation for more than 72h. Exclusion Criteria: - Exclusion criteria include immunosuppression, aspiration pneumonia, all types of pneumonia, sepsis and septic shock, tracheostomy, and pregnancy. |
Country | Name | City | State |
---|---|---|---|
Egypt | Menoufia University hospitals | Shibin Al Kawm | Menoufia |
Lead Sponsor | Collaborator |
---|---|
Menoufia University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | ventilator-associated pneumonia. | Clinical criteria for VAP include the following: worsened or development of new infiltrates in chest radiographs, body temperature less than 35°C or more than 38.5 °C, the leukocytic count below 4000 /mm3 or more than 11000/ mm3, tracheal aspirate of sputum or purulent discharge, and the demand for a positive end-expiratory pressure by more than 20% to keep oxygen saturation above 92% or the need for an increase in the inspired oxygen fraction. Each parameter is given a score of 0, 1, or 2. A score of 6 or more confirms VAP. | every day for 15 days | |
Secondary | Beck oral assessment score. | Examination of lips, gingiva, oral mucosa, tongue, teeth, and saliva each given 1 to 4 according to severity. a total score of 5 denotes no dysfunction while a score from 16 to 20 indicates severe dysfunction. | 4,8 and 12 hours after oral hygiene. | |
Secondary | Mechanical ventilation length. | Days spent by the patient on the ventilator. | up to 24 weeks. | |
Secondary | Mortality | Percentage of patients died from VAP. | up to 6 months. | |
Secondary | Length of ICU stay. | Number of days patients need to be discharged from ICU. | up to 24 weeks. |
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