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PeriOperative ISchemic Evaluation-3 Trial — POISE-3  

Venous Thrombosis Clinical Trial

Official title:
PeriOperative ISchemic Evaluation-3 Trial

Clinical Trial Summary

This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.

Clinical Trial Description

The POISE-3 study is a 10,000 patient, multicentre, international, non-inferiority randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy. The primary objective of the study is to determine; if TXA is superior to placebo for the occurrence of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic event; and to determine the impact of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of vascular death and major vascular events in patients who are followed for 30 days after noncardiac surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03505723
Study type Interventional
Source Population Health Research Institute
Contact
Status Completed
Phase Phase 3
Start date June 27, 2018
Completion date February 3, 2023
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