Venous Thromboembolism Clinical Trial
Official title:
Rate of Venous Thrombosis in Acutely Ill Patients Hospitalized in Internal Medicine Wards
After reports from observational studies suggesting an association between acutely ill medical patients and venous thromboembolism (VTE), interventional trials with anticoagulants drugs have demonstrated a significant reduction of VTE during and immediately after hospitalisation. Although several guidelines suggest the clinical relevance of reducing this outcome, there is a low tendency to use anticoagulants in patients hospitalised for acute medical illness. This observational multicentre study wants to evaluate the incidence of venous thrombo-embolism in acutely ill patients hospitalized in internal medicine wards.
Epidemiological studies have provided evidence of a high rate of thromboembolism in patients
hospitalised in medical wards. Based on this, several clinical trials with anticoagulants
including low-molecular-weight heparin (LMWH) and fondaparinux have been performed in
patients hospitalised for acute medical illness to prevent thromboembolism. Interventional
trials consistently showed that prophylaxis with anticoagulants reduces the risk of
composite endpoints of deep venous thrombosis (DVT), pulmonary embolism (PE) and DVT-related
death. These results prompted recommendation to the use anticoagulant prophylaxis in
patients hospitalised for acute medical illness, but, despite this, there is a widespread
underuse of anticoagulant prophylaxis in the medical wards of hospitals.
This observational multicentre study wants to evaluate the incidence of venous
thrombo-embolism in acutely ill patients hospitalized in internal medicine wards.
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