Valvular Heart Disease Clinical Trial
Official title:
Pathological Changes in the Cardiovascular System in Valvular Heart Disease: Validation of Non-invasive Markers
An observational cohort study of patients recruited presenting with valvular heart disease. The specialized investigations will focus on myocardial remodelling and scar formation/regression and extracardiac micro- and macro-vascular sequelae of valvular heart disease (VHD). The aim is to investigate the natural history of VHD and its ensuing cardiac and extracardiac end organ effects, the impact of existing interventions and the long-term outcome. We hope to establish the underlying causative aetiology of known associated conditions (e.g. vascular dementia) and to determine if extracardiac changes may serve as early biomarkers of prognosis in VHD. Participants will attend for two visits at Barts Heart Centre or Chenies Mews Imaging Centre and will undergo a panel of tests including cross-sectional cardiac imaging, point-of-care microvascular assessment and blood tests. Patient outcome will be assessed by data linkage to hospital episode statistic (HES) data and ONS data (via NHS spine). We aim to identify determinants that will help to improve patient selection and timing of valve intervention based on advanced clinical, blood and/or imaging biomarkers.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Completed |
NCT02241109 -
Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity
|
N/A | |
| Completed |
NCT03799133 -
Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery
|
N/A | |
| Completed |
NCT01676727 -
ADVANCE Direct Aortic Study
|
||
| Completed |
NCT01476995 -
Prognostic Indicators as Provided by the EPIC ClearView
|
N/A | |
| Completed |
NCT00721136 -
Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term Anticoagulation
|
N/A | |
| Recruiting |
NCT05014750 -
Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events
|
||
| Recruiting |
NCT05044338 -
Study on Standard Evaluation System and Optimal Treatment Path of Senile Valvular Heart Disease
|
||
| Recruiting |
NCT05015829 -
Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
|
||
| Recruiting |
NCT05078619 -
Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation
|
N/A | |
| Recruiting |
NCT06307262 -
European Registry of Transcatheter Repair for Tricuspid Regurgitation
|
||
| Completed |
NCT01624870 -
CoreValve Advance-II Study: Prospective International Post-market Study
|
||
| Completed |
NCT05708690 -
Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery
|
Phase 4 | |
| Recruiting |
NCT03797820 -
Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly（Mrs AVS）
|
||
| Recruiting |
NCT06077721 -
Milrinone on Right Ventricular Strain in Cardiac Surgery
|
||
| Not yet recruiting |
NCT04632914 -
Effect of Trunk Stabilizing Exercises on Patients With Median Sternotomy After Heart Valve Surgery
|
N/A | |
| Completed |
NCT01477151 -
Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery
|
Phase 4 | |
| Terminated |
NCT03590730 -
Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy
|
||
| Recruiting |
NCT06204783 -
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort II: Structural Heart Interventions (PLUTO-II)
|
||
| Enrolling by invitation |
NCT05775354 -
Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project
|
N/A |