Valve Heart Disease Clinical Trial
Official title:
A Multicenter Prospective, Randomized Controlled Study of Different Transfusion Thresholds in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB). Patients are randomly assigned to restrictive and liberal transfusion group and receive blood transfusion during and after surgery. Compare primary and secondary outcomes of two groups.
Patients are randomly assigned to restrictive-threshold group and liberal-threshold group before cardiac group. Patients are included in this research when their Hct meets 24% during CPB. Arterial blood gas analysis will be done in 0.5h, 1.5h, 2.5h, 3.5h...after CPB start and 0.5h before CPB finish. Arterial blood gas analysis will be done every 4h in intensive care unit(ICU) and everyday in general ward. Restrictive-threshold group: The transfusion threshold is Hemoglobin(Hb) ≤ 6.0g/dL or Hct ≤ 18% during CPB; postoperative Hb ≤ 7.0g/dL or Hct ≤ 21% in ICU or general ward. Liberal-threshold group: The transfusion threshold is Hb ≤ 8.0g/dL or Hct ≤ 24% during CPB; postoperative Hb ≤ 10.0g/dL or Hct ≤ 30% in ICU or general ward. If the Hb or Hct fall below the threshold at any time, 2 unit of blood cells is administered as soon as possible. Test Hb or Hct again, if is under the threshold 2 unit blood cells will be given until reach the threshold. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06066970 -
Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
|
||
| Recruiting |
NCT05079672 -
Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery
|
Phase 4 | |
| Completed |
NCT03347851 -
Post-surgical Aortic Hemodynamics After Aortic Valve Replacement
|
||
| Active, not recruiting |
NCT03539458 -
Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification
|
N/A | |
| Completed |
NCT04328090 -
Evaluation of the Potential Impact of Computerized Antimicrobial Stewardship
|
N/A | |
| Recruiting |
NCT04359030 -
Freestyle-Perimount Calcification Comparison
|
||
| Completed |
NCT04958668 -
Prospective Evaluation of Volatile Sedation After Heart Valve Surgery
|
N/A | |
| Completed |
NCT04598360 -
Release of Epoxyeicosatrienoic Acids From Erythrocytes During the Use of Extracorporeal Procedures (Heart-lung Machine)
|
N/A | |
| Not yet recruiting |
NCT04118621 -
Role of Chest Ultrasound in Detection of Post-operative Pulmonary Complications After Cardiothoracic Surgery
|
||
| Recruiting |
NCT06387446 -
Allogeneic Valve Transplantation
|
N/A | |
| Recruiting |
NCT04843072 -
Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis
|
N/A | |
| Completed |
NCT05804500 -
RecoveryPlus Telerehab Platform Pilot Study
|
N/A | |
| Recruiting |
NCT03885180 -
Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy
|
N/A | |
| Recruiting |
NCT06154018 -
Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass.
|
N/A | |
| Recruiting |
NCT06041308 -
Bioprothetic Valve Versus Mechanical Valve of Bioprothetic Valve Versus Mechanical Valve
|
||
| Suspended |
NCT01571791 -
Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery
|
Phase 2 | |
| Completed |
NCT06261788 -
Efficacy and Safety of the Sync-AV II Temporary Cardiac Pacing Catheter
|
N/A | |
| Completed |
NCT06079008 -
The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients
|
||
| Completed |
NCT04372654 -
Pilot Study Evaluating the Safety of Electroducer Sleeve Medical Device for Temporary Cardiac Stimulation During Percutaneous Cardiovascular Interventions, in All Kind of Patients
|
N/A | |
| Active, not recruiting |
NCT03661398 -
Caisson Transcatheter Mitral Valve Replacement (TMVR)
|
N/A |