Uterine Cancer Clinical Trial
Official title:
A Comparison Between Continuous Infusion vs. Patient Controlled Intraabdominal Injection of Local Anesthetics for Treatment of Postoperative Pain After Abdominal Hysterectomy. A Randomized, Double-blind Study.
Local anesthetics (LA) are increasingly used for postoperative pain management. Speicifically, several studies have found benefit of LA injected intra-abdominally following abdominal hysterectomy. However, it remains unclear whether the pain relief seen is due to local anesthetic mechanisms within the abdominal cavity or through systemic absorption. The aim of this study is to assess whether lidocaine administered intravenously has similar analgesic efficacy as the same dose administered intra-abdominally in patients undergoing abdominal hysterectomy. All patients would have rescue analgesia using the patient controlled analgesia (PCA) pump with morphine in order to achieve adequate pain management during 24 h.
Abdominal hysterectomy with or without salipingo-oophorectomy is associated with
moderate-severe postoperative pain. Poor pain control in the postoperative period can lead
to increased postoperative morbidities and poor quality of life. Furthermore, an emerging
clinical literature suggests that acute pain may rapidly evolve into chronic pain if poorly
treated. A meta-analysis of the literature found that > 30% patients had chronic pain one
year after abdominal hysterectomy (5). Therefore, efficient postoperative pain management is
imperative for the patient and is one of the new pain management standards recommended
recently.
Local anesthetics (LA) have been infiltrated subcutaneously, infused intra-abdominally, as
well as injected into the peritoneal cavity as a single dose at the end of the operation
following abdominal hysterectomy with variable effects. When injected as a single dose,
analgesia is limited to approximately 2-4 hours due to the short duration of action of local
anesthetics. In one recent study, the authors used a catheter inserted intra-abdominally and
local anesthetic or placebo infusion into the abdominal cavity for 24 h postoperatively and
found a reduction in postoperative analgesic requirements by 40% during 4-24 h. In another
study, the investigators found that LA injected intermittently intra-abdominally resulted in
better pain relief compared to intra-abdominal infusions.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03285802 -
Treatment Plan for an Individual Patient With Recurrent Uterine Papillary Serous Carcinoma (UPSC) With PIK3CA Gene Mutation
|
Phase 2/Phase 3 | |
Completed |
NCT01870947 -
Assisted Exercise in Obese Endometrial Cancer Patients
|
N/A | |
Active, not recruiting |
NCT04383210 -
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
|
Phase 2 | |
Not yet recruiting |
NCT05998811 -
Insights Into Participating in Studies for Uterine Cancer
|
||
Not yet recruiting |
NCT06369155 -
Azenosertib in Uterine Serous Carcinoma: Biomarker Study
|
Phase 2 | |
Completed |
NCT01432015 -
Fosaprepitant Versus Aprepitant in the Prevention of Chemotherapy Induced Nausea and Vomiting
|
Phase 4 | |
Completed |
NCT01399658 -
Image-Guided Gynecologic Brachytherapy
|
Phase 2 | |
Recruiting |
NCT02349958 -
Clinical Trial of Intraperitoneal Hyperthermic Chemotherapy
|
Phase 2 | |
Completed |
NCT00581646 -
Study of Psychosexual Impact of Cancer-Related Infertility in Women: Third Party Reproductive Assistance
|
N/A | |
Completed |
NCT00284427 -
Safety of Antioxidants During GYN Cancer Care
|
Phase 2 | |
Completed |
NCT00147680 -
Uterine Papillary Serous Cancer (UPSC) Trial
|
Phase 2 | |
Recruiting |
NCT05743517 -
Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)
|
N/A | |
Recruiting |
NCT05916196 -
[18F]FES PET/.CT in Uterine Cancer
|
Phase 2 | |
Withdrawn |
NCT04368130 -
SIGNAL:Identifying Behavioral Anomalies Using Smartphones to Improve Cancer Care
|
N/A | |
Active, not recruiting |
NCT03668340 -
AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma
|
Phase 2 | |
Completed |
NCT00588640 -
Study of D-Methadone in Patients With Chronic Pain
|
Phase 1/Phase 2 | |
Recruiting |
NCT05990426 -
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy
|
N/A | |
Completed |
NCT03701529 -
Effect of Anesthetic Agents on Optic Nerve Sheath Diameter
|
N/A | |
Recruiting |
NCT05758688 -
Whole Pelvis Proton Radiation for Gynecologic Cancer
|
N/A | |
Completed |
NCT01953107 -
Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates.
|
Phase 4 |