Uremic Pruritus Clinical Trial
Official title:
Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus
Uraemic pruritus (UP) remains a frequent and distressing problem in patients with advanced
or end-stage renal disease. Its intensity ranges from sporadic discomfort to complete
restlessness during both the day- and night-time and its distribution varies significantly
over time. Many attempts have been made to relieve this bothersome symptom in affected
patients, however with generally limited success. Incidence of UP varies widely between
studies and seems to decline over the last 30 years (from 85% in the 1970s and 50-60% in the
1980s to a 22% in the 2000s) (Gunal AI).
We use Pregabalin for the relief of diabetic neuropathic pain in patients on haemodialysis
in our centre. In addition to neuropathic pain, several of our patients have complained of
pruritus and after Pregabalin treatment, their pruritus has promptly and completely
resolved. Accordingly, we intend to conduct a double-blind, placebo-controlled, crossover
trial to assess the effectiveness of Pregabalin in chronic UP.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04728984 -
A Multi-site Bridging Study of Nalfurafine Hydrochloride Orally Disintegrating Tablet
|
Phase 3 | |
| Completed |
NCT02143973 -
Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus
|
Phase 2/Phase 3 | |
| Terminated |
NCT01660243 -
Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis
|
Phase 2 | |
| Completed |
NCT06159686 -
The Efficacy of Hemp-containing Cream Versus Placebo in the Treatment of Uremic Pruritus
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT05525234 -
A Study of Thalidomide in the Treatment of Refractory Uremic Pruritus
|
Phase 4 | |
| Completed |
NCT03002233 -
TRK-820 Study in Subjects on Hemodialysis With or Without Uremic Pruritus
|
Phase 1 | |
| Completed |
NCT03998163 -
CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
|
Phase 3 | |
| Active, not recruiting |
NCT05885737 -
Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus
|
Phase 3 | |
| Recruiting |
NCT04393675 -
Study to Investigate the Safety of LT5001 Drug Product for Uremic Pruritus in Hemodialysis Patients
|
Phase 1/Phase 2 | |
| Completed |
NCT03576235 -
Safety and Efficacy of PG102P for Uremic Pruritus in HD Patients
|
N/A | |
| Completed |
NCT05575193 -
Acupressure on Uremic Pruritus and Sleep Quality Among Patients Receiving Hemodialysis
|
N/A | |
| Completed |
NCT02858726 -
Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
|
Phase 2/Phase 3 | |
| Completed |
NCT02143648 -
Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
|
Phase 2/Phase 3 | |
| Completed |
NCT00494975 -
The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease
|
N/A | |
| Completed |
NCT03758079 -
Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus
|
Phase 4 | |
| Completed |
NCT02229929 -
Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
|
Phase 2 | |
| Completed |
NCT04639674 -
AST-120 in Hemodialysis Patients With Uremic Pruritus
|
Phase 4 | |
| Completed |
NCT03636269 -
CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
|
Phase 3 | |
| Completed |
NCT04711603 -
A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.
|
Phase 3 | |
| Completed |
NCT02696499 -
Treatment of Uremic Pruritus With PA101B
|
Phase 2 |