Uremic Pruritus Clinical Trial
Official title:
Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus: Pilot Study
This is a single blind randomized trial to compare efficacy and side effects of Gabapentin with Doxepin. Hemodialysis patients with uremic pruritus at one dialysis center of Saint George Hospital University Medical Centre were included in this study. Patients were divided into 2 groups to receive either 10 mg Doxepin daily or Gabapentin at a dose of 100mg after each hemodialysis session (increased as tolerated) for 4 weeks, after which patients were treated reversley. Pruritus severity and its effect on quality of life will be assessed by using visual analog scale (VAS), 5-D pruritus scale and dermatology life quality index (DLQI). Include patients will have to fill these forms at baseline and at end of week1, week2 and week4
Pruritus is one of the frustrating skin manifestations of advanced renal failure. Many
options have been used for the management of uremic pruritus (UP) such as Pregabalin,
Gabapentin, Doxepine and Desloratidine. Gabapentin, a GABAergic drug, has been found to be
effective in the treatment of uremic pruritus. Doxepin, a potent antihistamine drug, is used
orally or topically in many pruritic conditions such as UP, idiopathic pruritus, atopic
dermatitis, neurogenic, or psychogenic pruritus and, in the management of the UP in
hemodialysis patients.
No comparative head to head study between Gabapentin and Doxepine has been conducted to date.
The aim of this study was to compare Gabapentin and Doxepin in treatment of uremic pruritus
in hemodialysis patients.
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