Transcranial Magnetic Treatment (TMS) in Unipolar Depression

Unipolar Depression Clinical Trial

Official title:

Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00186784
• Other study ID #: TMS1871
• Status: Completed
• Phase: Phase 0
• First received: September 13, 2005
• Last updated: August 2, 2011
• Start date: December 2000
• Est. completion date: July 2011

Study information

• Verified date: August 2011
• Source: St. Joseph's Healthcare Hamilton
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Health Canada
• Study type: Interventional

Clinical Trial Summary

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Description:

Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: July 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Major Depression

• No physical health problems

Exclusion Criteria:

• History of Epilepsy

• Metal in the head/neck or skull

• Pacemaker

• Pregnancy

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Unipolar Depression

Intervention

Procedure:
• Transcranial Magnetic Stimulation (TMS)
treatment for 10 days

Locations

Country	Name	City	State
Canada	St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street	Hamilton	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
St. Joseph's Healthcare Hamilton	Queen's University, Kingston, Ontario

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hamilton Depression Rating Scale		Pre TMS and post TMS	No
Primary	Beck Depression Rating Scale		pre TMS and post TMS	No
Secondary	Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow		pre TMS and post TMS as well as post phase II, second set of TMS	No