Cost-effective Treatment of Unexplained Infertility

Status Not yet recruiting

Clinical Trial Summary

The issue of unexplained infertility that Southam brought up in 1960 is still a problem today. Despite improvements in infertility assessment, many couples still don't know why they are infertile. Even with the use of the most advanced ovulation detectors, fallopian tube patency tests, and semen evaluations, competency cannot identify every potential flaw in the intricate processes leading to conception. Unexplained infertility will be a challenge for both biological and clinical researchers since it results from these gaps in our understanding of fertilization and from our incapacity to use all of the current evidence-based information.

Clinical Trial Description

For the treatment of unexplained infertility, Clomiphene Citrate (CC) is frequently used either alone or in conjunction with intrauterine insemination (IUI). Its combined oestrogenic and anti-oestrogenic characteristics serve as the basis for the mechanism of action. When clomiphene citrate is used, the uterine blood flow is reduced during the peri-implantation stage of early luteal phase. About 80% of women experience ovulation, which has a cumulative effect over 6 to 8 months, yet the pregnancy rate in these women can still be relatively low. The endometrial and cervical mucus-level anti-oestrogenic actions of CC are the potential culprits. Without a doubt, one of the biggest obstacles in treating infertility is the endometrial impact. If the endometrial thickness (ET) is less than 6 mm, the pregnancy rate may be extremely low. Sildenafil citrate promotes endometrial thickness and uterine blood flow. The capacity of the blastocyst to penetrate the endometrium and establish a lasting blood supply is crucial for successful implantation. To do this, the blastocyst needs genes in order to create the required proteins for breaking down the endometrial cellular matrix, control cell development, and trigger angiogenesis. It can be difficult to understand the evidence on the efficacy and security of therapy for unexplained infertility. Given the substantial proportion of unaided pregnancies with expectant management, it is problematic that most studies do not include a placebo or untreated control group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06178523
Study type	Interventional
Source	Batterjee Medical College
Contact	Professor
Phone	00966126562415
Email	remah.kamel@bmc.edu.sa
Status	Not yet recruiting
Phase	Phase 4
Start date	January 1, 2024
Completion date	September 3, 2025

View Details

See also
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Completed	`NCT01672801` - Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT	N/A
Completed	`NCT01232465` - Impact of Sperm DNA Integrity on In Vitro Cycles	N/A
Not yet recruiting	`NCT01237535` - Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates	Phase 4
Completed	`NCT02272439` - Endocrine Disrupting Chemicals: Potential Effects on Male and Female Reproductive Health in Saskatchewan	N/A
Terminated	`NCT00650754` - Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility	Phase 2/Phase 3
Recruiting	`NCT04754243` - New Protocol in Unexplained Infertility	Phase 4
Completed	`NCT03018314` - Serum Kisspeptin Levels in Infertile Women	N/A
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Completed	`NCT02628756` - Endometrial Injury in Women With Unexplained Infertility	N/A
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Recruiting	`NCT03386552` - A Study of Lidocaine Pertubation as a Treatment for Unexplained Infertility	Phase 2
Completed	`NCT04465045` - Unexplained Infertility Treated by Hysteroscopy-laparoscopy
Completed	`NCT03461601` - Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility	N/A
Completed	`NCT01859520` - Swim up and Gradient Methods Used in Assisted Reproduction Techniques on DNA Fragmentation of Spermatozoa	N/A
Active, not recruiting	`NCT03828786` - Uterine Scratching in Intra-Uterine Insemination	N/A
Completed	`NCT03397693` - Assessment of Endometrial Thickness & Subendometrial Perfusion by 3D Power Doppler in Women With Unexplained Infertility and PCOS.
Withdrawn	`NCT04955574` - Probiotic and Antibiotic Therapies in Women With Unexplained Infertility	Phase 2
Not yet recruiting	`NCT03398993` - Effect of Endometrial Injury in Couples With Unexplained Infertility	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.