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Clinical Trial Summary

Interventional study of a group of patients with an inflammatory bowel disease (IBD; Crohn's disease (CD) or ulcerative colitis (UC)) to identify predictive and prognostic biomarkers of natural history and response to biotherapies.


Clinical Trial Description

Percentage of primary responders who haven't lost response to biotherapies during follow-up (anti-TNF, ustekinumab, vedolizumab). Response to treatment will be evaluated using objective criteria for measuring intestinal inflammation: endoscopic remission (endoscopic biopsy and surgical specimens), radiological (MRI), and / or biological (CRP, fecal calprotectin) . Response to therapy rates will be correlated with genomic, epigenomic, and microbiota data stratified by major environmental factors (nutrition, tobacco, physical activity). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03809728
Study type Interventional
Source Central Hospital, Nancy, France
Contact Adeline GERMAIN, MD, PhD
Phone +33383153120
Email a.germain@chru-nancy.fr
Status Recruiting
Phase N/A
Start date December 10, 2019
Completion date December 10, 2034

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