Clinical Trials Logo

Clinical Trial Summary

This study evaluates whether XDR Typhoid fever in children can be effectively treated with monotherapy (meropenum alone), or a combination (meropenum and azithromycin).


Clinical Trial Description

Complicated XDR Enteric fever is a very serious systemic disease, caused by an extremely resistant mutant strain of Salmonella Typhi ( the H58 S. Typhi superbug,) that as the name suggests is resistant to not only the first but also the second tier drugs conventionally used for treatment of the same. And as such, warrants immediate antibiotic therapy, but in view of the extended antimicrobial resistance the treatment options are limited to only two effective drugs viz Carbepenem and Azithromycin, as per culture sensitivity. So far, in the absence of universal standardized treatment protocols for XDR complicated typhoid fever in children, random use of either one or both in combination is the current practice. However, keeping antibiotic stewardship in mind, it is imperative to ascertain whether meropenum alone is effective or should be combined with azithromycin in the treatment of this serious disease. Our study therefore compares the efficacy of monotherapy with meropenum or combination with azithromycin based on clinical and microbiologic remission, shortened hospital stay and less chances of relapse in order to then formulate a standardized protocol to treat complicated XDR typhoid in children thus preventing yet further antimicrobial resistance. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04154722
Study type Interventional
Source Ziauddin University
Contact
Status Completed
Phase Phase 4
Start date June 20, 2019
Completion date December 30, 2020

See also
  Status Clinical Trial Phase
Completed NCT04830371 - Non-inferiority and Safety Study of EuTCV Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants Phase 2/Phase 3
Recruiting NCT04543877 - WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study Early Phase 1
Completed NCT02324751 - Vaccines Against Salmonella Typhi Phase 2
Completed NCT01421693 - Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Phase 4
Completed NCT05579821 - Evaluation Study of DPP® Typhoid Assay
Completed NCT02947295 - Global Genomic and Proteomic Profiling of African Children With Typhoid Fever
Completed NCT01405521 - Understanding Typhoid Disease After Vaccination Phase 2
Completed NCT00386789 - Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age N/A
Completed NCT04801602 - Commercial Typhoid Tests Validation Trial
Recruiting NCT06104345 - Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines Phase 4
Completed NCT01438996 - Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Phase 2
Completed NCT01437267 - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Phase 2
Completed NCT01193907 - Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Phase 2
Recruiting NCT04349826 - The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial) Phase 4
Completed NCT01608815 - Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Phase 3
Completed NCT01123941 - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Phase 1
Recruiting NCT05500482 - Vellore Typhoid Vaccine Impact Trial Phase 4
Completed NCT03926455 - Safety and Immunogenicity of Typhax, a Typhoid Vaccine Phase 1
Completed NCT01229176 - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Phase 2
Completed NCT03956524 - Safety and Tolerability of Typhoid Conjugate Vaccine (EuTCV) in Healthy Adults Phase 1