Early Basal Insulin Administration in Adult Diabetic Ketoacidosis

Status Terminated

Clinical Trial Summary

Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management

Clinical Trial Description

The transition from IV Insulin Infusion (IVII) to Subcutaneous Long-acting insulin injections in Diabetic Ketoacidosis (DKA) management frequently results in rebound hyperglycemia, particularly if there are high insulin requirements that can adversely affect the DKA recovery, increase Length Of Stay (LOS), morbidity, and mortality. Investigators propose a prospective, open-label, intervention, non-randomized, controlled study to test the hypothesis that an insulin glargine dose of 0.4 Units/kg early administered (within four hours) of IVII initiation in DKA management in adult would be effective and safe in shortening the time to anion gap closure comparing to the standard practice. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04567225
Study type	Interventional
Source	The Cleveland Clinic
Contact
Status	Terminated
Phase	Phase 4
Start date	October 1, 2020
Completion date	August 27, 2021

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