Type 2 Diabetes Clinical Trial
Official title:
Abnormal Glucose Tolerance is Associated With a Reduced Myocardial Metabolic Flexibility in Patients With Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. The investigators aimed at verifying whether this pattern is influenced by the presence of abnormal glucose tolerance (AGT).
A catheter is advanced into the coronary sinus by fluoroscopy to withdraw venous blood. A
unipolar pacing catheter is positioned into the right atrium. Arterial sampling is done from
the femoral artery introducer catheter.
The study protocol consisted of 3 steps (Rest, Pacing and Recovery), during which timed
blood samples are collected to measure plasma NEFA and glucose. After the instrumentation is
completed, Rest arterio-venous sampling is performed at time -15 min and 0 min. After the 0
min, heart rate is increased by atrial pacing to 110 bpm for 3 minutes and to 130 bpm for 3
additional minutes and arterio-venous sampling is repeated at the end of each step (at time
3 and 6 min). Pacing is then stopped and at time 1, 5, 15 and 30 min into the Recovery
period other pairs of arterial and venous samples are withdrawn.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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