Type 2 Diabetes Clinical Trial
Official title:
Arterial Wall Calcium Load and Preferential Sites in Pseudoxanthoma Elasticum Versus Type 2 Diabetes and Chronic Kidney Disease.
Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.
In a previous work we have observed that patients suffering from PXE, a soft-tissue
calcifying inherited autosomal disease, exhibited specific structural and functionnal
features within the peripheral arteries. We now want to quantify and determine the
preferential sites of the arterial wall calcification (Agatston score) between these
patients compared to diabetics and patients with chronic renal insufficiency with
mediacalcosis.
All variables will be collected from a cohort of PXE monitored in our PXE Health and Care
centre at the university hospital of Angers. Quantification of the arterial wall calcium
load will be performed using helicoidal CT-scan. These variables will be compared to the
same measurements performed in type 2 diabetic and chronic kidney disease patients paired by
age and gender.
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Observational Model: Case Control, Time Perspective: Prospective
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