Type 2 Diabetes Clinical Trial
Official title:
LIRAGLUTIDE AND ORLISTAT TREATMENT FOR PERSISTENT TYPE 2 DIABETES AFTER GASTRIC BANDING: A PILOT STUDY
The purpose of this study is to determine whether addition of 1 or 2 medicines after gastric banding can improve remission of type 2 diabetes.
Liraglutide and Orlistat improve glycemic control by increasing glucagon-like-peptide-1
(GLP-1) response and fat malabsorption, respectively but do not reverse type 2 diabetes.
Roux-en-y gastric bypass (RYGB) surgery reverses type 2 diabetes 84% of the time while the
less invasive, reversible laparoscopic adjustable gastric banding (LAGB) procedure reverses
type 2 diabetes 48% of the time.
Decreased caloric intake occurs after RYGB and LAGB but increased post-prandial GLP-1
response and fat malabsorption only occur after RYGB. Since FDA-approved agents Liraglutide
and Orlistat increase GLP-1 response and fat malabsorption, respectively, it is of
significant clinical interest to determine if addition of Liraglutide and/or Orlistat can
improve type 2 diabetes remission rates in the 52% of patients who have not achieved diabetes
reversal after gastric banding.
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