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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT04255433
Other study ID # 17073
Secondary ID I8F-MC-GPGN2019-
Status Active, not recruiting
Phase Phase 3
First received
Last updated
Start date May 29, 2020
Est. completion date June 2025

Study information

Verified date May 2024
Source Eli Lilly and Company
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 13299
Est. completion date June 2025
Est. primary completion date June 2025
Accepts healthy volunteers No
Gender All
Age group 40 Years and older
Eligibility Inclusion Criteria: - Have a diagnosis of type 2 diabetes - Have confirmed atherosclerotic cardiovascular disease - HbA1c =7.0% to =10.5% - Body mass index (BMI) =25 kilograms per meter squared (kg/m²) Exclusion Criteria: - Have had a major cardiovascular event within the last 60 days - Have type 1 diabetes mellitus - Have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months - Are currently planning treatment for diabetic retinopathy and/or macular edema - Currently planning a coronary, carotid, or peripheral artery revascularization - Have a history of pancreatitis - Have a history of ketoacidosis or hyperosmolar state/coma - Have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery - Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years - Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) - Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement

Study Design


Intervention

Drug:
Tirzepatide
Administered SC
Dulaglutide
Administered SC

Locations

Country Name City State
Argentina Instituto de Investigaciones Clínicas Bahia Blanca Bahía Blanca Buenos Aires
Argentina Asociación de Beneficencia Hospital Sirio Libanés Buenos Aires
Argentina CEMEDIC Buenos Aires
Argentina Centro Médico Viamonte Buenos Aires Ciudad Autónoma De Buenos Aires
Argentina CIPREC Buenos aires
Argentina Glenny Corp Buenos Aires
Argentina Mautalen Salud e Investigación Buenos Aires Ciudad Autónoma De Buenos Aires
Argentina CEMEDIAB C.a.b.a. Ciudad Autónoma De Buenos Aires
Argentina CEDIC Caba Buenos Aires
Argentina Organizacion Medica de Investigacion Caba Buenos Aires
Argentina Centro Medico Privado CEMAIC Capital Córdoba
Argentina Stat Research S.A. Capital Federal Buenos Aires
Argentina Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada Ciudad Autonoma de Buenos Aires Ciudad Autónoma De Buenos Aires
Argentina Centro de Investigaciones Metabólicas (CINME) Ciudad Autónoma de Buenos Aires Buenos Aires
Argentina Centro Medico Privado San Vicente Diabetes Cordoba Córdoba
Argentina Centro Diabetológico Dr. Waitman Córdoba
Argentina CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani Córdoba
Argentina Centro Universitario de Investigación en Farmacologia Clínic Corrientes
Argentina Instituto de Cardiología "Juana F. Cabral" Corrientes
Argentina Instituto de Investigaciones Clínicas Mar del Plata Mar del Plata Buenos Aires
Argentina DIM Clínica Privada Ramos Mejía Buenos Aires
Argentina Instituto de Investigaciones Clinicas Rosario Rosario Santa Fe
Argentina Instituto Médico Catamarca IMEC Rosario Santa Fe
Argentina Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica Rosario Santa Fe
Argentina Instituto Médico Alas Salta
Argentina Centro Medico Privado de Reumatologia SAN M. DE Tucuman Tucumán
Argentina Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L San Miguel de Tucuman Tucumán
Argentina Investigaciones Clínicas Tucumán San Miguel de Tucuman Tucumán
Argentina Go Centro Medico San Nicolás San Nicolas Buenos Aires
Argentina Sanatorio Norte Santiago del Estero
Argentina INECO Neurociencias Oroño Zárate Buenos Aires
Australia Nightingale Research Adelaide South Australia
Australia Royal Adelaide Hospital Adelaide South Australia
Australia Box Hill Hospital Box Hill Victoria
Australia Core Research Group Brisbane Queensland
Australia Mater Misericordiae Limited Brisbane Queensland
Australia Royal Brisbane and Women's Hospital Brisbane Queensland
Australia Victorian Heart Hospital Clayton Victoria
Australia School of Medicine, Fremantle Hospital Fremantle Western Australia
Australia Barwon Health Geelong Victoria
Australia Austin Health - Repatriation Hospital Heidelberg West Victoria
Australia GenesisCare Joondalup Western Australia
Australia Launceston General Hospital Launceston Tasmania
Australia The AIM Centre / Hunter Diabetes Centre Merewether New South Wales
Australia GenesisCare Murdoch Western Australia
Australia Southern Adelaide Diabetes & Endocrine Services Oaklands Park South Australia
Australia Nepean Hospital Penrith New South Wales
Australia Gold Coast University Hospital Southport Queensland
Australia University of Sydney - Charles Perkins Centre Sydney New South Wales
Australia The Townsville Hospital Townsville Queensland
Australia Illawarra Shoalhaven Local Health District Wollongong New South Wales
Austria Medizinische Universität Graz Graz Steiermark
Austria Uniklinikum Salzburg Salzburg
Austria Klinik Hietzing Wien
Austria Klinik Landstraße Wien
Austria Medizinische Universität Wien Wien
Austria Zentrum für klinische Studien Dr Hanusch Gmbh Wien
Belgium Onze Lieve Vrouw Ziekenhuis Aalst Aalst Oost-Vlaanderen
Belgium Imelda General Hospital Bonheiden Antwerpen
Belgium Algemeen Ziekenhuis klina Brasschaat Antwerpen
Belgium AZ Sint-Jan Brugge-Oostende AV Brugge West-Vlaanderen
Belgium Université Libre de Bruxelles - Hôpital Erasme Brussels Bruxelles-Capitale, Région De
Belgium UZ Brussel Brussels Bruxelles-Capitale, Région De
Belgium Antwerp University Hospital Edegem Antwerpen
Belgium AZ Groeninge Campus Kennedylaan Kortrijk West-Vlaanderen
Belgium UZ Leuven Leuven Vlaams-Brabant
Belgium Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman Liège
Belgium ZNA Jan Palfijn Merksem Vlaams Gewest
Belgium Az Damiaan vzw Oostende West-Vlaanderen
Belgium AZ Delta vzw Roeselare West-Vlaanderen
Belgium AZ Nikolaas Sint-Niklaas Oost-Vlaanderen
Brazil Instituto de Pesquisa clinica de Campinas Campinas São Paulo
Brazil Loema Instituto de Pesquisa Clinica Campinas São Paulo
Brazil Pesquisa Clínica em Diabetes - Dra Rosângela Réa Curitiba Paraná
Brazil Private Practice - Dr.Miguel N. Hissa Fortaleza Ceará
Brazil CECIP - Centro de Estudos do Interior Paulista Jaú São Paulo
Brazil Núcleo de Pesquisa Clínica do Rio Grande do Sul Porto Alegre Rio Grande Do Sul
Brazil IBPClin - Instituto Brasil de Pesquisa Clínica Rio de Janeiro
Brazil Faculdade de Medicina do ABC Santo Andre São Paulo
Brazil ISPEM - Instituto São José dos Campos em Pesquisas Médicas São José dos Campos São Paulo
Brazil CPCLIN Sao Paulo São Paulo
Brazil Instituto de Pesquisa Clinica Sao Paulo São Paulo
Brazil CPQuali Pesquisa Clínica São Paulo
Brazil Hospital das Clinicas FMUSP São Paulo
Brazil Obesidade e Doenças Metabolicas São Paulo
Brazil CEDOES Vitória Espírito Santo
Canada LMC Clinical Research Inc. (Barrie) Barrie Ontario
Canada Aggarwal and Associates Limited Brampton Ontario
Canada LMC Diabetes & Endocrinology Brampton Ontario
Canada LMC Diabetes & Endocrinology Calgary Alberta
Canada Cambridge Cardiac Care Centre Cambridge Ontario
Canada LMC Clinical Research Inc. (Thornhill) Concord Ontario
Canada Viacar Recherche Clinique Greenfield Park Quebec
Canada NSHA-QEII Health Sciences Centre-Dickson Bldg Halifax Nova Scotia
Canada Centre de Recherche Clinique de Laval Laval Quebec
Canada Manna Research Lévis Quebec
Canada Milestone Research Inc. London Ontario
Canada St. Joseph's Health Care London Ontario
Canada Clinique Sante Cardio MC Montreal Quebec
Canada North York Diagnostic and Cardiac Centre North York Ontario
Canada LMC Clinical Research Inc. (Oakville) Oakville Ontario
Canada Private Practice - Dr. James Cha Oshawa Ontario
Canada LMC Manna Research Ottawa Ontario
Canada Kawartha Cardiology Clinical Trials Peterborough Ontario
Canada Diex Recherche Quebec Inc. Quebec
Canada Bluewater Clinical Research Group Inc. Sarnia Ontario
Canada Diabetes Clinic Smiths Falls Ontario
Canada Janik Research Corporation Sudbury Ontario
Canada Canadian Phase Onward Toronto Ontario
Canada Diabetes Heart Research Centre Toronto Ontario
Canada Dr. Anil K. Gupta Medicine Professional Corporation Toronto Ontario
Canada LMC Clinical Research Inc. (Bayview) Toronto Ontario
Canada BC Diabetes Office Vancouver British Columbia
Canada Dr. M.B. Jones Inc. Victoria British Columbia
Canada Winnipeg Clinic Winnipeg Manitoba
China Beijing Anzhen Hospital, Capital Medical University Beijing Beijing
China Beijing Friendship Hospital Beijing Beijing
China Peking University First Hospital Beijing Beijing
China Peking University People's Hospital Beijing Beijing
China China-Japan Union Hospital Changchun Jilin
China Hunan Provincial People's Hospital ChangSha Hunan
China The First Affiliated Hospital, Sun Yat-sen University Guangzhou Guangdong
China The Fourth Hospital of Harbin Medical University Harbin Heilongjiang
China First Huai'an Hospital Affiliated to Nanjing Medical University Huai'an Jiangsu
China Jinan Central Hospital Jinan Shandong
China Lanzhou university second hospital Lanzhou Gansu
China The First Hospital of Lanzhou University Lanzhou Gansu
China The First Affiliated Hospital of Nanchang University Nanchang Jiangxi
China Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu
China The Second Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu
China Zhongda Hospital Southeast University Nanjing Jiangsu
China Nanjing First Hospital Nanjing Shi Jiangsu
China Jiangxi Pingxiang People's Hospital Pingxiang Jiangxi
China The People's Hospital of Liaoning Province Shenyang Liaoning
China Tianjin Medical University General Hospital Tianjin Tianjin
China The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi
China General Hospital of Ningxia Medical University Yinchuan Ningxia
China Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu
Czechia Diacentrum Brandys n.L. s.r.o. Brandys nad Labem Praha-východ
Czechia MUDr. Alena Vachova Ceske Budejovice Jihoceský Kraj
Czechia MUDr. Tomas Edelsberger Krnov Moravskoslezský Kraj
Czechia Interni a diabetologicka ordinace, s.r.o. Nachod Náchod
Czechia Diabet2 s.r.o., diabetologicka a interni ambulance Praha Praha 1
Czechia ResTrial s.r.o. Praha Praha 8
Czechia Vseobecna fakultni nemocnice v Praze Praha 2
Czechia Milan Kvapil s.r.o., Diabetologicka ambulance Praha 4
Czechia MUDr. Michala Pelikanova s.r.o. Praha 4
Czechia MUDr. Barbora Diepoltova Praha 9 - Klanovice Praha 9
France Centre Hospitalier Sud Francilien Corbeil-Essonnes Île-de-France
France Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand Dijon Côte-d'Or
France Hôtel-Dieu du Creusot - site Harfleur Le Creusot Bourgogne
France Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière Paris
France Groupe hospitalier Paris saint Joseph Paris Île-de-France
France Hôpital Bichat - Claude-Bernard Paris
France CHU Bordeaux Haut-Leveque Pessac Aquitaine
France Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes Saint-Herblain Loire-Atlantique
France CHU Rangueil Toulouse cedex 9 Haute-Garonne
France Groupe Hospitalier Mutualiste Les Portes du Sud Vénissieux Rhône-Alpes
Germany Studienzentrum Aschaffenburg Aschaffenburg Bayern
Germany Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen Bad Oeynhausen Nordrhein-Westfalen
Germany CIMS Studienzentrum Bamberg Bamberg Bayern
Germany Diabetespraxis Prenzlauer Alle Berlin
Germany Institut für klinische Forschung und Entwicklung Berlin
Germany Diabetes- und Stoffwechselpraxis Bochum Bochum Nordrhein-Westfalen
Germany Gemeinschaftspraxis Dres. Jung Deggingen Baden-Württemberg
Germany Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer Dortmund Nordrhein-Westfalen
Germany Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien Dresden Sachsen
Germany Universitaetsklinikum Carl Gustav Carus Dresden Dresden Sachsen
Germany Gemeinschaftspraxis für Diabetologie Eisenach Thüringen
Germany ZKS Suedbrandenburg Elsterwerda Brandenburg
Germany InnoDiab Forschung Gmbh Essen Nordrhein-Westfalen
Germany Medizentrum Essen Borbeck Essen Nordrhein-Westfalen
Germany Private Practice - Dr. Bernd Becker Essen Nordrhein-Westfalen
Germany ZKS Dr. Lüdemann Falkensee Brandenburg
Germany ClinPhenomics GmbH & Co KG Frankfurt Hessen
Germany Practice Dr.med. Denger and Dr.med. Pfitzner Friedrichsthal Saarland
Germany MVZ im Altstadt-Carree Fulda GmbH Fulda Hessen
Germany Diabetes Zentrum Dr. Tews Gelnhausen Hessen
Germany Diabetes Zentrum Wilhelmsburg Hamburg
Germany Diabeteszentrum Hamburg West Hamburg
Germany Diabetologische Schwerpunktpraxis Harburg Hamburg
Germany St. Josefskrankenhaus Heidelberg Heidelberg
Germany Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weißenfels Hohenmölsen Sachsen-Anhalt
Germany AmBeNet GmbH Leipzig Sachsen
Germany Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut Leipzig Sachsen
Germany SIBAmed GmbH Leipzig Sachsen
Germany Private Practice - Dr. Ilka Simon-Wagner Lichtenfels Bayern
Germany Universität zu Lübeck - Institut für Endokrinologie und Diabetes Lübeck Schleswig-Holstein
Germany Study department Ludwigshafen am Rhein Rheinland-Pfalz
Germany Praxis Oedeme Lüneburg Niedersachsen
Germany SMO.MD GmbH Magdeburg Sachsen-Anhalt
Germany CDG Studienambulanz Hartard München Bayern
Germany Institut für Diabetesforschung GmbH Münster Münster Nordrhein-Westfalen
Germany RED-Institut GmbH Oldenburg Schleswig-Holstein
Germany Private Practice - Dr. Christine Kosch Pirna Sachsen
Germany Diabetologische Schwerpunktpraxis Marck Linn Pickel Pohlheim Hessen
Germany Diabetologische Schwerpunktpraxis und Praxis für Allgemeinmedizin Dr. Veronika Wenzl-Bauer null Josef Wenzl Rehlingen Niedersachsen
Germany Private Practice - Dr. Joachim Weimer Reinfeld Schleswig-Holstein
Germany MVZ Riesa am Klinikum Döbeln GmbH Riesa Sachsen
Germany Zentrum für klinische Studien Saint Ingbert Saarland
Germany Medizinisches Versorgungszentrum am Bahnhof Spandau Spandau Berlin
Germany Diabetologische Schwerpunktpraxis Diabetologikum Speyer Speyer Rheinland-Pfalz
Germany Marienhospital Stuttgart Stuttgart Baden-Württemberg
Germany Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob Villingen-Schwenningen Baden-Württemberg
Germany Praxis Sauter & Sauter & Vorbach Wangen Baden-Württemberg
Germany Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis Zwenkau Sachsen
Greece Athens Euroclinic Athens Attikí (Region)
Greece General Hospital of Athens "G. Gennimatas" Athens Attikí
Greece Attikon General University Hospital Chaidari Attikí
Greece University General Hospital of Larissa Larissa Thessalía
Greece Iatriko Paleou Falirou Medical Center Paleo Faliro Attikí (Region)
Greece Thermi Clinic Thermi, Thessaloniki Thessaloníki
Greece Euromedica General Clinic of Thessaloniki Thessaloniki Thessaloníki
Greece Papageorgiou General Hospital of Thessaloniki Thessaloniki Thessaloníki
Greece AHEPA University General Hospital of Thessaloniki Thessaloníki
Greece Ippokrateio General Hospital of Thessaloniki Thessaloníki Kentrikí Makedonía
Hungary DRC Gyógyszervizsgáló Központ Balatonfüred Veszprém
Hungary ClinDiab Kft. Budapest
Hungary Magyar Honvedseg Egeszsegugyi Kozpont Budapest
Hungary Strazsahegy Medicina Bt. Budapest
Hungary Szent János Kórház Budapest
Hungary Szent Margit Rendelointézet Nonprofit Kft Budapest
Hungary Debreceni Egyetem - Kenézy Gyula Egyetemi Oktatókórház Debrecen Hajdú-Bihar
Hungary Debreceni Egyetem Klinikai Kozpont Debrecen
Hungary Markhot Ferenc Oktatókórház Eger Heves
Hungary Pharma 4 Trial Gyöngyös Heves
Hungary Studium Egeszseghaz Kft Kalocsa Bács-Kiskun
Hungary Selye János Kórház Komárom Komárom-Esztergom
Hungary Kanizsai Dorottya Korhaz Nagykanizsa Zala
Hungary Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ Szeged Csongrád
Hungary Fejér Megyei Szent György Egyetemi Oktató Kórház Szekesfehervar Fejér
Hungary CLINFAN Szolgáltató Kft Szekszárd Tolna
Hungary Zala Megyei Szent Rafael Kórház Zalaegerszeg Zala
India CIMS Hospital - Care Institute of Medical Sciences Ahmedabad Gujarat
India Gujarat Endocrin Pvt Ltd Ahmedabad Gujarat
India Bangalore Diabetes Centre Bangalore Karnataka
India Madras Diabetes Research Foundation Chennai Tamil Nadu
India Care Hospitals Hyderabad- Banjara Hills Hyderabad Telangana
India CARE CHL-Hospitals Indore Madhya Pradesh
India Apollo Gleneagles Hospitals Kolkata Kolkata West Bengal
India King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College Mumbai Maharashtra
India Topiwala National Medical College & B. Y. L. Nair Charitable Hospital Mumbai Maharashtra
India Kingsway Hospitals (Best Multispeciality Hospital in Nagpur) Nagpur Maharashtra
India All India Institute of Medical Sciences New Delhi Delhi
India Batra Hospital and Medical Research Centre New Delhi Delhi
India G.B. Pant Institute of Postgraduate Medical Education & Research New Delhi Delhi
India Sir Ganga Ram Hospital New Delhi Delhi
Israel Emek Medical Center Afula HaTsafon
Israel Barzilai Medical Center Ashkelon HaDarom
Israel Clalit Health Services - Atlit Atlit ?eifa
Israel Soroka Medical Center Be'er Sheva HaDarom
Israel Hillel Yaffe Medical Center Hadera HaTsafon
Israel Bnai Zion Medical Center Haifa ?eifa
Israel Linn Medical Center Haifa
Israel Rambam Health Care Campus Haifa HaTsafon
Israel Diabetes Medical Center Holon Tell Abib
Israel Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem Jerusalem Yerushalayim
Israel Hadassah Medical Center Jerusalem Yerushalayim
Israel Hadassah Mount Scopus Medical Centre Jerusalem Yerushalayim
Israel Shaare Zedek Medical Center Jerusalem Yerushalayim
Israel Meir Medical Center Kfar Saba HaMerkaz
Israel Galilee Medical Center Nahariya HaTsafon
Israel Holy Family Hospital Nazareth HaTsafon
Israel Rabin Medical Center Petah-Tikva HaMerkaz
Israel Rabin Medical Center - Hasharon Campus Petah-Tikva HaMerkaz
Israel Sheba Medical Center Ramat Gan HaMerkaz
Israel Sheba Medical Center Ramat Gan HaMerkaz
Israel Kaplan Medical Center Rehovot HaMerkaz
Israel ZIV Medical Center Safed HaTsafon
Israel Clalit Health Services - Sakhnin Community Clinic Sakhnin HaTsafon
Israel Sourasky Medical Center Tel Aviv Tell Abib
Italy A.O.U.C. Policlinico di Bari Bari Puglia
Italy Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo Lombardia
Italy IRCCS - AOU di Bologna Bologna
Italy Azienda Ospedaliera Garibaldi Catania
Italy Azienda Ospedaliera Mater Domini Catanzaro
Italy Ospedale Maggiore Pronto Soccorso Chieri Torino
Italy Università degli Studi Gabriele D' Annunzio Chieti
Italy Azienda Ospedaliera Universitaria Careggi Firenze Toscana
Italy Centro Cardiologico Monzino MIlano
Italy Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano Lombardia
Italy Universita degli Studi della Campania Luigi Vanvitelli Napoli Campania
Italy Ospedale san Giovanni di Dio-Diabetologia Olbia Sardegna
Italy A.O.U. Policlinico Paolo Giaccone Palermo Sicilia
Italy Azienda Ospedaliero Universitaria di Parma Parma
Italy Fondazione Salvatore Maugeri Clinica del lavoro Pavia
Italy Azienda Ospedaliera Universitaria Pisana Pisa Toscana
Italy Fondazione Policlinico Universitario Agostino Gemelli Roma Lazio
Italy Fatebenefratelli Isola Tiberina - Gemelli Isola Rome Lazio
Italy Fondazione Policlinico Tor Vergata Rome Lazio
Italy Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento Verona Veneto
Japan Tokyo-Eki Center-building Clinic Chuo Ku Tokyo
Japan Fukuwa Clinic Chuo-ku Tokyo
Japan The Institute for Adult Disease, Asahi Life Foundation Chuo-ku Tokyo
Japan Jinnouchi Hospital Kumamoto
Japan Medical Corporation Sato Medical clinic Ootaku Tokyo
Japan AMC Nishiumeda Clinic Osaka
Japan Sakurabashi Watanabe Hospital Osaka
Japan Takatsuki Red Cross Hospital Takatsuki Osaka
Japan Uji-Tokushukai Medical Center Uji Kyoto
Korea, Republic of Keimyung University Dongsan Hospital Daegu Taegu-Kwangyokshi
Korea, Republic of Asan Medical Center Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Hallym University Kangnam Sacred Heart Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Korea University Anam Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Kyung Hee University Hospital at Gangdong Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Seoul National University Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Severance Hospital, Yonsei University Health System Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of The Catholic Univ. of Korea Seoul St. Mary's Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Ulsan University Hospital Ulsan Ulsan-Kwangyokshi
Korea, Republic of Yonsei University-Wonju Severance Christian Hospital Wonju Kang-won-do
Mexico Centro de Investigacion Medica Aguascalientes Aguascalientes
Mexico Fundación Cardiovascular de Aguascalientes A.C. Aguascalientes
Mexico Hospital Cardiologica Aguescalientes Aguascalientes
Mexico Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos Chihuahua
Mexico Centro de Estudios de Investigacion Metabolicos y Cardiovasculares Ciudad Madero Tamaulipas
Mexico Instituto de Diabetes, Obesidad y Nutricion Cuernavaca Morelos
Mexico Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C. Culiacan Sinaloa
Mexico Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia Durango
Mexico Centro de Investigacion Medica Integral Guadalajara Jalisco
Mexico Diseno y Planeacion en Investigacion Medica Guadalajara Jalisco
Mexico Instituto Jalisciense de Investigacion en Diabetes y Obesidad Guadalajara Jalisco
Mexico Private Practice - Dr. Arechavaleta Granell Maria del Rosario Guadalajara Jalisco
Mexico Salud Cardiovascular Guadalajara Jalisco
Mexico Unidad de Investigacin Clnica Cardiometabolica de Occidente Guadalajara Jalisco
Mexico Universidad de Guadalajara Guadalajara Jalisco
Mexico Medical Care and Research SA de CV Merida Yucatán
Mexico Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares Mexico City Distrito Federal
Mexico Cardiolink Clin Trials Monterrey Nuevo León
Mexico Hospital Universitario "Dr. Jose Eleuterio Gonzalez" Monterrey Nuevo León
Mexico Centro de Estudios Clínicos de Querétaro (CECLIQ) Querétaro
Mexico Unidad Médica para la Salud Integral San Nicolás de los Garza Nuevo León
Mexico Centro de Investigacion Cardiovascular y Metabólica Tijuana Baja California
Mexico Hospital Angeles Xalapa Xalapa Veracruz
Mexico Centro de Investigacion Medica de Occidente, S.C. Zapopan Jalisco
Netherlands EB Utrecht Almere Flevoland
Netherlands Ziekenhuis Amstelland Amstelveen Noord-Holland
Netherlands Amsterdam UMC, locatie AMC Amsterdam Noord-Holland
Netherlands Amsterdam UMC, locatie VUmc Amsterdam Noord-Holland
Netherlands Ziekenhuis Rijnstate Arnhem Gelderland
Netherlands Reinier de Graaf Ziekenhuis, locatie Delft Delft
Netherlands Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland Dirksland Zuid-Holland
Netherlands Slingeland Ziekenhuis Doetinchem Gelderland
Netherlands Ziekenhuis Gelderse Vallei Ede Gelderland
Netherlands Spaarne Gasthuis, Haarlem Zuid Haarlem Noord-Holland
Netherlands Saxenburgh Medisch Centrum Hardenberg Overijssel
Netherlands Ziekenhuis Bethesda Hoogeveen Drenthe
Netherlands Canisius-Wilhelmina Ziekenhuis Nijmegen Gelderland
Netherlands Radboudumc Nijmegen Gelderland
Netherlands Franciscus Gasthuis & Vlietland, Locatie Gasthuis Rotterdam Zuid-Holland
Netherlands Jeroen Bosch ziekenhuis s-Hertogenbosch Noord-Brabant
Netherlands Diakonessenhuis, locatie Utrecht Utrecht
Netherlands Universitair Medisch Centrum Utrecht Utrecht
Poland Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna Bialystok Podlaskie
Poland SN ZOZ Lege Artis Poradnia Diabetologiczna Bialystok Podlaskie
Poland Centrum Badan Klinicznych PI-House sp. z o.o. Gdynia Pomorskie
Poland NZOZ Salvia CM Katowice Slaskie
Poland NZOZ Diab-Endo-Met Krakow Malopolskie
Poland Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna Lodz Lódzkie
Poland CenterMed Lublin NZOZ Lublin Lubelskie
Poland Gabinety TERPA Lublin Lubelskie
Poland NZOZ Medica Lublin Lubelskie
Poland Gaja Poradnie Lekarskie Maciej Wiza Poznan Wielkopolskie
Poland OMEDICA Medical Center Poznan Wielkopolskie
Poland Private Practice - Dr. Ewa Krzyzagorska Poznan Wielkopolskie
Poland NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki Ruda Slaska Slaskie
Poland Private Practice - Dr. Robert Witek Tarnów Malopolskie
Poland Instytut Diabetologii Warsaw Mazowieckie
Poland Centrum Medyczne AMED Warszawa Mazowiecki
Poland ETG Warszawa Warszawa Mazowieckie
Poland NZOZ Regionalna Poradnia Diabetologiczna Wroclaw Dolnoslaskie
Poland Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej Wroclaw Dolnoslaskie
Puerto Rico Advanced Clinical Research, LLC Bayamon
Puerto Rico Manati Center for Clinical Research Manati
Puerto Rico Research and Cardiovascular Corp. Ponce
Puerto Rico GCM Medical Group, PSC - Hato Rey Site San Juan
Puerto Rico San Juan City Hospital San Juan
Romania Private Practice - Dr. Diana Barbonta Alba Iulia Alba
Romania CMI Dr.Pletea Noemi SRL Bacau
Romania SC Minimed SRL Bacau
Romania CMI DNBM Dr. Pop Lavinia Baia Mare Maramure?
Romania C.M.D.T.A. Neomed Brasov Bra?ov
Romania Centrul Medical NutriLife Bucharest Bucure?ti
Romania Geea Medical Easy Diet Bucharest Bucure?ti
Romania Nicodiab Bucharest Bucure?ti
Romania The National Institute of Diabetes, Nutrition and Metabolic Diseases "Prof. Dr. N. Paulescu" Bucharest Bucure?ti
Romania Top Diabet SRL Craiova Dolj
Romania Diamed Obesity Gala?i
Romania Centrul Medical Consultmed Ia?i
Romania Olimpia Med Ia?i
Romania Gama Diamed Mangalia Constan?a
Romania Centrul Medical Grandmed Oradea Bihor
Romania Diabdana Oradea Bihor
Romania Diabmed Dr. Popescu Alexandrina Ploie?ti Prahova
Romania Dianutrilife Medica Ploiesti Prahova
Romania SC Dentosim Queen SRL - Centrul Medical Diamed Targu-Mures Mure?
Romania Centru Medical Dr. Negrisanu Timisoara Timi?
Russian Federation Saint-Petersburg City Hospital of Saint Elizabeth ?????-????????? Sankt-Peterburg
Russian Federation First Moscow State Medical University I.M. Sechenov ?????? Moskva
Russian Federation Arkhangelsk Regional Clinical Hospital Arkhangelsk Arkhangel'skaya Oblast'
Russian Federation First City Clinical Hospital E.E. Volosevich Arkhangelsk Arkhangel'skaya Oblast'
Russian Federation Endocrinology Research Center of Rosmedtechnologies Moscow Moskva
Russian Federation First Moscow State Medical University I.M. Sechenov Moscow Moskva
Russian Federation M. F. Vladimirskiy Moscow Regional Research Clinical Institute Moscow Moskva
Russian Federation Moscow City Clinical Hospital Number 52 Moscow Moskva
Russian Federation Moscow City Clinical Hospital Number 52 Moscow Moskva
Russian Federation National Medical Research Center for therapy and preventive medicine Moscow Moskva
Russian Federation Pirogov Russian National Research Medical University Moscow Moskva
Russian Federation Russian Cardiology Research and Production Complex Moscow Moskva
Russian Federation Novosibirsk State Medical University Novosibirsk Novosibirskaya Oblast'
Russian Federation Rostov State Medical University Rostov-on-Don Rostovskaya Oblast'
Russian Federation Ryazan Regional Clinical Cardiological Dispensary Ryazan Ryazanskaya Oblast'
Russian Federation Ryazan Regional Clinical Cardiological Dispensary Ryazan Ryazanskaya Oblast
Russian Federation City Mariinskaya Hospital Saint Petersburg Leningradskaya Oblast
Russian Federation S.M. Kirov Military Medical Academy Saint Petersburg Sankt-Peterburg
Russian Federation Astarta Clinic Saint-Petersburg Sankt-Peterburg
Russian Federation Regional Clinical Hospital of the Saratov Region Saratov Saratovskaya Oblast'
Russian Federation Advisory Diagnostic Centre Syktyvkar Komi, Respublika
Russian Federation Sibneyromed Urban Neurological Center Tomsk Tomskaya Oblast'
Russian Federation Tomsk Regional Clinical Hospital Tomsk Tomskaya Oblast'
Russian Federation Research & Practice Yaroslavl Yaroslavskaya Oblast'
Russian Federation Yaroslavl State Med Acad Clinical Hospital Yaroslavl Yaroslavskaya Oblast'
Slovakia Diacrin s.r.o. Bratislava Bratislavský Kraj
Slovakia IN-DIA Lucenec Banskobystrický Kraj
Slovakia Sin Azucar Malacky Bratislavský Kraj
Slovakia Funkystuff Nove Zamky Nitriansky Kraj
Slovakia Diabetol Prešov Prešovský Kraj
Slovakia DIA-MED CENTRUM s.r.o. Puchov Trenciansky Kraj
Slovakia DIAB sro Rožnava Košický Kraj
Slovakia DIAB sro Roznava Košický Kraj
Slovakia MED-DIA s.r.o Sabinov Prešovský Kraj
Slovakia Diabetes Centrum Trencin Trenciansky Kraj
Spain CHUAC-Complejo Hospitalario Universitario A Coruña A Coruña A Coruña [La Coruña]
Spain Hospital Universitario Príncipe de Asturias Alcalá de Henares Madrid, Comunidad De
Spain Centro Periférico de Especialidades Bola Azul Almeria Almería
Spain Hospital Universitario de La Ribera Alzira València
Spain Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval Ferrol A Coruña [La Coruña]
Spain Hospital Unviersitario Virgen Nieves Granada
Spain Hospital Universitario La Paz Madrid
Spain Hospital Universitario Ramón y Cajal Madrid Madrid, Comunidad De
Spain Hospital Universitario Virgen de la Victoria Malaga Andalucía
Spain Hospital Universitario Central de Asturias Oviedo Asturias, Principado De
Spain Hospital Universitario Quironsalud Madrid Pozuelo de Alarcón Madrid
Spain Hospital Virgen del Camino Sanlúcar de Barrameda Cádiz
Spain CHUS - Hospital Clinico Universitario Santiago de Compostela A Coruña [La Coruña]
Spain Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE) Sevilla
Spain Hospital Quiron Infanta Luisa Sevilla Andalucía
Spain Hospital Universitario Virgen Macarena Sevilla
Spain Hospital General Universitario de Valencia Valencia Valenciana, Comunitat
Spain Hospital Universitari i Politecnic La Fe València
Spain Hospital Clínico Universitario de Valladolid Valladolid Castilla Y León
Spain Hospital Virgen de las Montañas Villamartin Cádiz
Sweden ProbarE Lund Skåne Län [se-12]
Sweden Sahlgrenska Universitetssjukhuset Mölndal Mölndal Västra Götalands Län [se-14]
Sweden Universitetssjukhuset Örebro Örebro Örebro Län [se-18]
Sweden Östersunds Sjukhus Östersund Jämtlands Län [se-23]
Sweden Dalecarlia Clinical Research Center Rättvik Dalarnas Län [se-20]
Sweden Citydiabetes Stockholm Stockholms Län [se-01]
Taiwan Changhua Christian Hospital Changhua County Changhua
Taiwan Mackay Memorial Hospital-Hsinchu Hsinchu City Hsinchu
Taiwan Hualien Tzu Chi Medical Center Hualien City Hualien
Taiwan Chang Gung Memorial Hospital at Kaohsiung Kaohsiung Niao Sung Dist Kaohsiung
Taiwan Taichung Veterans General Hospital Taichung
Taiwan National Cheng Kung University Hospital Tainan
Taiwan Chi Mei Medical Center Tainan City Tainan
Taiwan Taipei Veterans General Hospital Taipei
Taiwan Chang Gung Medical Foundation-Linkou Branch Taoyuan
Turkey Ankara University Medicine Hospital Ankara
Turkey Akdeniz Universitesi Hastanesi Antalya
Turkey Aydin Adnan Menderes Universitesi Hastanesi Aydin
Turkey Dokuz Eylul Universitesi Hastanesi Balçova Izmir
Turkey Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre Denizli
Turkey Atatürk Üniversitesi Erzurum
Turkey Eskisehir Osmangazi University Eskisehir Eskisehir
Turkey Gaziantep Üniversitesi Gaziantep Onkoloji Hastanesi Gaziantep
Turkey Acibadem Universitesi Atakent Hastanesi Istanbul
Turkey Dr. Sadi Konuk Egitim ve Arastirma Hastanesi Istanbul
Turkey Fatih Sultan Mehmet Training and Research Hospital Istanbul
Turkey Göztepe Eitim Ve Aratrma Hastanesi Istanbul
Turkey Koç Üniversitesi Hastanesi Istanbul
Turkey Ege Universitesi Hastanesi Izmir
Turkey Erciyes Universitesi Tip Fakultesi Hastaneleri Kayseri
Turkey Kocaeli Üniversitesi Kocaeli
Turkey Inönü Üniversitesi Turgut Özal Tip Merkezi Malatya
Turkey Dicle Üniversitesi SUR Diyarbakir
Turkey Mersin University Medical Faculty Yenisehir Mersin
Turkey Baskent University Dr. Turgut Noyan Research and Training Center Yuregir Adana
Ukraine Municipal non-profit enterprise "City Hospital #7" of Zaporizhzhia City Council ????????? Zaporizka Oblast
Ukraine Chernivetsky Oblasny Endokrynologichny Centr, Oblasna Komunalna Ustanova Chernivtsi Chernivetska Oblast
Ukraine Dnipropetrovsk City Clinical Hospital No. 9 Dnipro Dnipropetrovska Oblast
Ukraine Ukrainian State Research Institute Of Medical And Social Problems Of Disability Dnipro Dnipropetrovska Oblast
Ukraine City Clinical Hospital No. 2 Kharkiv Kharkivska Oblast
Ukraine L.T. Mala National Institute of Therapy of NAMS of Ukraine Kharkiv Kharkivska Oblast
Ukraine Municipal Non-Profit Enterprise "City clinical hospital ?8" of Kharkiv city council Kharkiv Kharkivska Oblast
Ukraine ARTEM Kiev Kyivska Oblast
Ukraine Institute of Endocrinology and Metabolism named after Komissarenko Kiev Kyiv
Ukraine Institute of Endocrinology and Metabolism named after Komissarenko Kiev Kyiv
Ukraine Medical Center of Limited Liability Company "Medical Center "Consilium Medical" Kiev Kyiv
Ukraine Medbud Clinic Kyiv Kyivska Oblast
Ukraine Medical Center Ok!Clinic+ Kyiv
Ukraine Lviv City Clinical Hospital #4 Lviv Lvivska Oblast
Ukraine Lviv Regional Endocrinology Dispensary Lviv Lvivska Oblast
Ukraine Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council Odesa Odeska Oblast
Ukraine Municipal non-profit enterprise "Consultative-diagnostic center ?20" of Odesa city council Odessa Odeska Oblast
Ukraine Municipal enterprise "1st City clinical hospital of Poltava City Council", Poltava State Medical University Poltava Poltavska Oblast
Ukraine Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho Poltava Poltavska Oblast
Ukraine Municipal Non-Profit Enterprise Of Sumy Regional Council ''Sumy Regional Clinical Hospital'' Sumy Sumska Oblast
Ukraine Vinnytsia Regional Clinical Endocrinology Dispensary Vinnytsia Vinnytska Oblast
United Kingdom Aberdeen Royal Infirmary Aberdeen Aberdeen City
United Kingdom Southmead Hospital Bristol Bristol, City Of
United Kingdom Ninewells Hospital and Medical School Dundee Angus
United Kingdom Staploe Medical Centre Ely Cambridgeshire
United Kingdom Glasgow Royal Infirmary Glasgow Glasgow City
United Kingdom Hull and East Yorkshire Hospitals NHS Trust Hull Kingston Upon Hull
United Kingdom Ipswich Hospital Ipswich Suffolk
United Kingdom Leicester General Hospital Leicester Leicestershire
United Kingdom University Hospital Aintree Liverpool
United Kingdom Knowle House Surgery Plymouth Devon
United Kingdom Morriston Hospital Swansea Swansea [Abertawe Gb-ata]
United Kingdom The Royal Cornwall Hospital Truro England
United States Albany Medical College, Division of Community Endocrinology Albany New York
United States Ellipsis Group Alpharetta Georgia
United States Orlando Heart & Vascular Institute, LLC Altamonte Springs Florida
United States Northwest Heart Clinical Research Arlington Heights Illinois
United States Atlanta Diabetes Associates Atlanta Georgia
United States University of Colorado Anschutz Medical Campus Aurora Colorado
United States Maryland Cardiovascular Specialists Baltimore Maryland
United States Heritage Valley Medical Group, Inc. Beaver Pennsylvania
United States Billings Clinic Billings Montana
United States University of Alabama at Birmingham Medical Center Birmingham Alabama
United States Elite Clinical Trials Blackfoot Idaho
United States Excel Medical Clinical Trials Boca Raton Florida
United States Brigham and Women's Hospital Diabetes Program Boston Massachusetts
United States Joslin Diabetes Center Boston Massachusetts
United States Qualmedica Research Bowling Green Kentucky
United States Holston Medical Group Bristol Tennessee
United States Mercury Street Medical Group, PLLC Butte Montana
United States Capital Area Research, LLC Camp Hill Pennsylvania
United States Ralph H. Johnson VA Medical Center Charleston South Carolina
United States Atrium Health - Department of Family Medicine Research Charlotte North Carolina
United States Cedar-Crosse Research Center Chicago Illinois
United States Cleveland Clinic Foundation Cleveland Ohio
United States John Muir Medical Center - Concord Campus Concord California
United States Private Practice - Dr. Osvaldo A. Brusco Corpus Christi Texas
United States Valley Clinical Trials, Inc. Covina California
United States Dallas Diabetes Research Center Dallas Texas
United States Galenos Research Dallas Texas
United States North Texas Endocrine Center Dallas Texas
United States Research Institute of Dallas Dallas Texas
United States Texas Health Physicians Group Dallas Texas
United States Physicians' Research Options Draper Utah
United States Kaiser Permanente - Dutluth, GA Duluth Georgia
United States Duke University Durham North Carolina
United States St. John's Hospital Edina Minnesota
United States Academy of Diabetes, Thyroid and Endocrine El Paso Texas
United States AMCR Institute Escondido California
United States The University of Kansas - Clinical Research Center Fairway Kansas
United States Virginia Heart Falls Church Virginia
United States Lillestol Research Fargo North Dakota
United States Decpa, Llc Feasterville Pennsylvania
United States Diabetes and Thyroid Center of Ft. Worth Fort Worth Texas
United States Valley Research Fresno California
United States NorCal Medical Research, Inc Greenbrae California
United States Tribe Clinical Research, LLC Greenville South Carolina
United States Clinical Investigation Specialists Gurnee Illinois
United States CMR of Greater New Haven Hamden Connecticut
United States Encore Medical Research Hollywood Florida
United States East-West Medical Research Institute Honolulu Hawaii
United States VA Pacific Islands Health Care System Honolulu Hawaii
United States Northwest Houston Cardiology - Cypress Houston Texas
United States MedStar Health Research Institute (MedStar Physician Based Research Network) Hyattsville Maryland
United States Rocky Mountain Clinical Research Idaho Falls Idaho
United States University of Iowa Iowa City Iowa
United States East Coast Institute for Research, LLC Jacksonville Florida
United States Encore Research Group- Jacksonville Center for Clinical Research Jacksonville Florida
United States NSC Research Johns Creek Georgia
United States Clinical Investigation Specialists Kenosha Wisconsin
United States PMG Research, Inc. d/b/a PMG Research of Knoxville Knoxville Tennessee
United States UCSD - Altman Clinical and Translational Research Institute (ACTRI) La Jolla California
United States Diabetes and Endocrine Associates La Mesa California
United States First Valley Medical Group Lancaster California
United States Accel Research Sites Network - St. Pete-Largo Clinical Research Unit Largo Florida
United States Palm Research Center Sunset Las Vegas Nevada
United States Palm Research Center Tenaya Las Vegas Nevada
United States Physicians Research Associates Lawrenceville Georgia
United States L-MARC Research Center Louisville Kentucky
United States East Coast Institute for Research at The Jones Center Macon Georgia
United States M Health Fairview St. John's Hospital Maplewood Minnesota
United States Endocrine Clinic Memphis Tennessee
United States Southern Endocrinology Associates Mesquite Texas
United States ActivMed Practices and Research Methuen Massachusetts
United States Monterey Endocrine & Diabetes Institute, Inc. Monterey California
United States PMG Research Inc., d/b/a PMG of Piedmont Healthcare Mooresville North Carolina
United States Riverside University Health System - Medical Center Moreno Valley California
United States Accellacare - Mt Pleasant Mount Pleasant South Carolina
United States Southern Nh Diabetes and Endocrinology Nashua New Hampshire
United States Intend Research, LLC Norman Oklahoma
United States Infinity Medical Research North Dartmouth Massachusetts
United States North Hills Family Medicine/North Hills Medical Research North Richland Hills Texas
United States Ocala Caridovascular Research Ocala Florida
United States Advanced Research Institute Ogden Utah
United States University Of Nebraska Medical Center Omaha Nebraska
United States VA Nebraska-Western Iowa Health Care System Omaha Nebraska
United States Diabetes Associates Medical Group Orange California
United States Qualmedica Research, LLC Owensboro Kentucky
United States MD Medical Research Oxon Hill Maryland
United States Cardiology Partners Clinical Research Institute - Palm Beach Gardens Palm Beach Gardens Florida
United States Pasadena Clinical Research Pasadena California
United States Northeast Endocrine Metabolic Associates Philadelphia Pennsylvania
United States Thomas Jefferson University Hospital Philadelphia Pennsylvania
United States Office 18 Pittsburgh Pennsylvania
United States Idaho State University Pocatello Idaho
United States Peace River Cardiovascular Center Port Charlotte Florida
United States MultiCare Good Samaritan Hospital Puyallup Washington
United States Monument Health Rapid City Hospital Rapid City South Dakota
United States Endocrine and Metabolic Consultants Rockville Maryland
United States CentraCare Heart & Vascular Center Saint Cloud Minnesota
United States StudyMetrix Research Saint Peters Missouri
United States Professional Health Care of Pinellas Saint Petersburg Florida
United States Alpine Medical Group Salt Lake City Utah
United States Audie L Murphy VA Hospital San Antonio Texas
United States Norcal Endocrinology & Internal Medicine San Ramon California
United States VA Puget Sound Health Care System Seattle Washington
United States Consano Clinical Research, LLC Shavano Park Texas
United States Multicare Institute for Research and Innovation Spokane Washington
United States Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative Springfield Illinois
United States Clinvest Research LLC Springfield Missouri
United States Mercy Research - Smith Glynn Callaway Springfield Missouri
United States Northwest Houston Heart Center Tomball Texas
United States Cotton O'Neil Clinical Research Center Topeka Kansas
United States Cotton O'Neil Clinical Research Center - Central Office Topeka Kansas
United States Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance California
United States Arcturus Healthcare , PLC, Troy Internal Medicine Research Division Troy Michigan
United States Atlanta Heart Specialists Tucker Georgia
United States Coastal Metabolic Research Centre Ventura California
United States Chase Medical Research Waterbury Connecticut
United States Cardiology Partners Clinical Research Institute - Wellington Wellington Florida
United States Central Washington Health Services Association d/b/a Confluence Health Wenatchee Washington
United States Iowa Diabetes and Endocrinology Research Center West Des Moines Iowa
United States Kalo Clinical Research West Valley City Utah
United States Great Lakes Medical Research, LLC Westfield New York
United States PMG Research of Wilmington, LLC Wilmington North Carolina
United States Clinical Research of Central Florida Winter Haven Florida
United States Cardiology Consultants of Philadelphia Yardley Yardley Pennsylvania

Sponsors (1)

Lead Sponsor Collaborator
Eli Lilly and Company

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Canada,  China,  Czechia,  France,  Germany,  Greece,  Hungary,  India,  Israel,  Italy,  Japan,  Korea, Republic of,  Mexico,  Netherlands,  Poland,  Puerto Rico,  Romania,  Russian Federation,  Slovakia,  Spain,  Sweden,  Taiwan,  Turkey,  Ukraine,  United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Time to First Occurrence of Death from Cardiovascular (CV) Causes, Myocardial Infarction (MI), or Stroke (MACE-3) Time to First Occurrence of a component event of MACE-3 Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to Death from Any Cause Time to Death from Any Cause Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to CV Death Time to CV Death Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of MI Time to First Occurrence of MI Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of Stroke Time to First Occurrence of Stroke Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits End of Study (Approximate Maximum 54 Months)
Secondary Percentage of Participants with More than 10% Weight Loss Percentage of Participants with More than 10% Weight Loss 36 Months
Secondary Change from Baseline in Body Weight Change from Baseline in Body Weight Baseline, End of Study (Approximate Maximum 54 Months)
Secondary Change from Baseline in Hemoglobin A1c (HbA1c) Change from Baseline in HbA1c Baseline, End of Study (Approximate Maximum 54 Months)
Secondary Change from Baseline in Urinary Albumin to Creatinine Ratio Change from Baseline in Urinary Albumin to Creatinine Ratio Baseline, End of Study (Approximate Maximum 54 Months)
Secondary Change from Baseline in Blood Lipids Change from Baseline in Blood Lipids (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides) Baseline, End of Study (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of Revascularization Time to First Occurrence of Revascularization Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of Hospitalization Due to Unstable Angina Time to First Occurrence of Hospitalization Due to Unstable Angina Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Time to First Occurrence of New or Worsening Nephropathy Time to First Occurrence of New or Worsening Nephropathy Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke End of Study (Approximate Maximum 54 Months)
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