Type 2 Diabetes Mellitus Clinical Trial
Official title:
Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes.
Microbiota is important for immunology, hormonal and metabolic homeostasis in human and could
influence on developing diabetes and obesity. Recent studies investigates microbiota by
metagenomic sequencing, however, the composite of microbiota and its metabolic role has not
been fully determined. Metagenomics and microbiome analysis could early diagnose metabolic
disorders and suggest treatment options for metabolic diseases.
In this study, the investigators investigate the composite of microbiota and deduct basic
information for treatment models using metagenomic sequencing.
1. Cross-section study: normal/prediabetes/drug naïve type2 diabetes: compare microbiota
using metagenomic sequencing among three groups.
2. Observational prospective study: metformin/sodium glucose co-transporter 2 (SGLT2)
inhibitor/ezetimibe: compare microbiota using metagenomic sequencing before and after
drug treatment.
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