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Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell — TOND  

Type 2 Diabetes Mellitus Clinical Trial

Official title:
Exploring Effective and Safety Therapies Which Protect Islet β Cell on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity

Clinical Trial Summary

Prevalence of diabetes is increasing rapidly both in China and all over the world.Hyperglycemia is an important risk factor and major hazard to cardiovascular and cerebrovascular diseases and even dangerous to human health."High glucose toxicity "cause pancreatic β cell non-physiologic and irreversible damage.It is an important cause of β cell dysfunction.High glucose toxicity further suppresses insulin secretion of β cell, further even β-cell function failure.It is urgent to explore more effective and safety treatments which can also protect islet cells function.How to release high glucose toxicity , reverse the toxic effects of hyperglycemia on islet β cells as early as possible, and to maximize recover and protect the pancreatic β cell function is the keypoints of this study.Our aim is to explore the non-inferiority of new antidiabetic drugs DPP4 inhibitors on releasing glucose toxicity and protecting islet β cell function compared with traditional treatments on newly diagnosed type 2 diabetes,compare efficacy and safety of different oral antidiabetic drugs and insulin on newly diagnosed type 2 diabetes patients with high glucose toxicity and compare differences of different oral antidiabetic drugs and insulin on protecting pancreatic β-cell function.

Clinical Trial Description

Patients were divided into 3 groups:

1. DPP-4 inhibitor treatment group (45 cases): DPP-4 inhibitor (sitagliptin phosphate) combined with metformin and/or acarbose;

2. insulin treatment group (45 cases): insulin (insulin glargine or insulin detemir) and/or metformin;

3. Sulfonylureas treatment group (45 cases): sulfonylureas combined with metformin and/or acarbose; ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03180281
Study type Interventional
Source First Affiliated Hospital Xi'an Jiaotong University
Contact Jing Sui, Doctor
Phone 0086-18991989230
Email suijing1029@163.com
Status Not yet recruiting
Phase N/A
Start date July 1, 2017
Completion date January 1, 2020
View Details
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