Type 2 Diabetes Mellitus Clinical Trial
Official title:
Effect of Arginase Inhibition on Microvascular Endothelial Function in Patients With Type 2 Diabetes and Microvascular Dysfunction.
The present project is designed to test the hypothesis that arginase contributes to microvascular endothelial dysfunction in patients with type 2 diabetes and microvascular complications.
Background
The development of microvascular complications in diabetes is a complex process, in which
endothelial dysfunction is of importance. Emerging evidence suggests that arginase is a key
mediator of endothelial dysfunction in type 2 diabetes mellitus (T2DM) by reciprocally
regulating nitric oxide bioavailability. The aim of this study was to test the hypothesis
that arginase activity is increased and that arginase contributes to microvascular
endothelial function in patients with T2DM and microvascular dysfunction.
Method
Microvascular endothelium-dependent and -independent vasodilatation are investigated in
patients with T2DM (n =12) and healthy age-matched control subjects (n =12) with
laser-Doppler flowmetry during iontophoretic application of acetylcholine and sodium
nitroprusside, respectively, before and after intra-arterial administration of the arginase
inhibitor N-hydroxy-nor-L-arginine (0.1 mg/min) for 120 min.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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