Type 2 Diabetes Mellitus Clinical Trial
Official title:
Effect of DPP-IV Inhibitors on Occurence of Cancers and the Mechanism Using AGE and RAGE in Patients With Type 2 Diabetes
Recently, DPP-IV inhibitors are used as a novel way to augment the incretin system and one
of the newest classes of medications in the treatment of type 2 diabetes mellitus (T2DM).
Since the DPP-IV inhibitor was first used, about 5 years have passed in USA. However, there
were no major side effects including occurrence of cancers. The main mechanism for DPP-IV
inhibitors is due to suppress the function of DPP-IV activity. As it is known that the
suppressed DPP-IV activity is a marker for early diagnosis of cancers, the reason of
disassociation is not clear.
Activation of receptor for advanced glycation endproduct (AGE) is related to sideration of
cancers. Meanwhile, the DPP-IV inhibitors may be related to inhibit the activation of
receptor for AGE (RAGE). Therefore, DPP-IV inhibitors may work as a cancer protective agent
in diabetes by blocking the AGE-RAGE axis.
However, it is not demonstrated why DPP-IV inhibitors have no side effect of occurrence of
cancer via blocking the activation of AGE-RAGE.
The investigators examined effect of DPP-IV inhibitors on frequency of cancers and the
underlying mechanism using AGE and RAGE before and 5 years after administration of DPP-IV
inhibitors in Japanese patients with T2DM.
The AGE and RAGE are measured using ELISA method in the laboratory of Department of Pathophysiology and Therapeutics of Diabetes Vascular Complications, Kurume University, School of Medicine, Japan before and for 5 years after administration of DPP-IV inhibitors. ;
Observational Model: Cohort, Time Perspective: Prospective
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