Evaluation of Exenatide in Patients With Diabetic Neuropathy

Status Completed

Clinical Trial Summary

This study will look at whether or not the medication exenatide improves signs and symptoms of diabetic peripheral neuropathy in people with type 2 diabetes and mild to moderate diabetic peripheral neuropathy.

Clinical Trial Description

This study will look at the effects of the medication exenatide on peripheral neuropathy in people with type 2 diabetes. Exenatide (trade name, BYETTA®) is an injectable medication used by people with type 2 diabetes to control blood sugar. Peripheral neuropathy is a complication of diabetes that can cause symptoms such as numbness, tingling or burning sensations in the feet and hands. Controlling blood sugars levels in type 2 diabetes is thought to prevent, delay or improve the damage to the nerve fibers that causes peripheral neuropathy. There is also some evidence that exenatide may have additional beneficial effects on the peripheral nerves, beyond the benefits of blood sugar control alone. In this study, about half of the participants will take exenatide by injection twice daily and the other half will take insulin glargine (Lantus®) by injection once daily. Both groups are expected to have similar improvement in blood sugar control. This study will show whether exenatide has beneficial effects on neuropathy beyond the benefits of better blood sugar control alone. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00855439
Study type	Interventional
Source	University of Michigan
Contact
Status	Completed
Phase	N/A
Start date	June 2008
Completion date	May 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02771093` - An Exploratory Study of the Effects of Trelagliptin and Alogliptin on Glucose Variability in Patients With Type 2 Diabetes Mellitus	Phase 4
Completed	`NCT02545842` - Assessment Study of Three Different Fasting Plasma Glucose Targets in Chinese Patients With Type 2 Diabetes Mellitus (BEYOND III/FPG GOAL)	Phase 4
Recruiting	`NCT03436212` - Real-Life Home Glucose Monitoring Over 14 Days in T2D Patients With Intensified Therapy Using Insulin Pump.	N/A
Completed	`NCT03244800` - A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.	Phase 2
Completed	`NCT03960424` - Diabetes Management Program for Hispanic/Latino	N/A
Withdrawn	`NCT02769091` - A Study in Adult Patients With Nonalcoholic Steatohepatitis Who Also Have Type 2 Diabetes	Phase 2
Recruiting	`NCT06065540` - A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor	Phase 3
Recruiting	`NCT05008276` - Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Completed	`NCT04091373` - A Study Investigating the Pharmacokinetics of a Single Dose Administration of Cotadutide	Phase 1
Completed	`NCT03296800` - Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects	Phase 1
Recruiting	`NCT06212778` - Relationship Between Nutritional Status, Hand Grip Strength, and Fatigue in Hospitalized Older Adults With Type 2 Diabetes Mellitus.
Completed	`NCT05979519` - Fresh Carts for Mom's to Improve Food Security and Glucose Management	N/A
Recruiting	`NCT05579314` - XW014 in Healthy Subjects and Patients With Type 2 Diabetes Mellitus (T2DM)	Phase 1
Completed	`NCT03859934` - Metabolic Effects of Melatonin Treatment	Phase 1
Terminated	`NCT03684642` - Efficacy and Safety of Efpeglenatide Versus Dulaglutide in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin	Phase 3
Completed	`NCT03248401` - Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes	Phase 4
Completed	`NCT03644134` - A Personalized Intervention to Manage Physiological Stress and Improve Sleep Patterns	N/A
Completed	`NCT05295160` - Fasting-Associated Immune-metabolic Remission of Diabetes	N/A
Completed	`NCT02836873` - Safety and Efficacy of Bexagliflozin in Type 2 Diabetes Mellitus Patients With Moderate Renal Impairment	Phase 3
Completed	`NCT02252224` - Forxiga (Dapagliflozin) Regulatory Postmarketing Surveillance