Type 2 Diabetes Mellitus Clinical Trial
Official title:
Postprandial Dysmetabolism - The Effects of Monounsaturated vs. Saturated Lipids on Lipid and Carbohydrate Metabolism and Inflammation in Healthy 1st Degree Relatives of Patients With Type 2 Diabetes.
Type 2 diabetes (T2D) is a common disease associated with multiple complications and an
increased risk of cardiovascular morbidity and mortality. Also, it is a heavy economical
burden on society. 1st degree relatives of patients with T2D have an increased risk of
developing T2D. This risk can be modified by the ingested diet: a traditional north European
diet rich in saturated fat increases the risk, while a Mediterranean diet rich in
monounsaturated fat protects from development of T2D and cardiovascular disease.
T2D is a part of the metabolic syndrome consisting of T2D, hypertension, adipositas,
dyslipidemia and steatosis. The pathogenesis of the metabolic syndrome is partly explained
by fasting dyslipidemia, postprandial dysmetabolism (derangement of lipid and carbohydrate
metabolism) and impaired metabolic flexibility. Partly, it can be explained by a chronic
low-grade inflammation in peripheral tissue. The dysmetabolism and the inflammation are
correlating entities exerting their influence through common biochemical pathways. This is
established in patients with T2D, but sparsely studied in healthy relatives of patients with
T2D.
In this project, the investigators will study postprandial dysmetabolism, inflammation,
oxidative stress, adipocytokines, incretins, appetite regulating hormones and the expression
of the genes involved in above mentioned. We will compare healthy 1st degree relatives of
patients with T2D with healthy controls with no family history of T2D and look into
differences in the response to meal stimulation with respectively saturated and
monounsaturated fat. The subjects will be thoroughly examined with a hyperinsulinaemic
euglycaemic clamp and a DEXA scan. Before and after the meal stimulation, we will perform
calorimetry (in order to determine the metabolic rates), take blood samples and perform
muscle and fat tissue biopsies. The biopsies will be used for studies of a vast number of
genes.
The project will give us new valuable knowledge about the interaction between the
intermediate metabolism and the innate immune system and the early pre-diabetic changes in
the 1st degree relatives of patients with T2D. In the long run, the project will contribute
to improving our guidance and treatment of persons at risk of developing T2D.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)
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