Type 1 Diabetes Clinical Trial
Official title:
The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes
The aims of this study are two fold: To show whether there is an increased environmental or genetic susceptibility to stress in patients with T1D and whether it influences diabetes management. And to develop a strategy for the assessment and treatment of patients with T1D and an increased risk for development of psychopathology under stress.
Lately, a marked increase in the incidence and earlier age of onset of type 1 diabetes (T1D)
has been noted. These observations could also be connected to an increased prevalence of
stressful experiences and a lowered stress tolerance in some children.
The way a person responds to stress is determined by the interplay of genetic and
environmental factors. Environmental experiences at specific times of development have been
shown to shape individual's hypothalamic-pituitary-adrenal axis (HPA axis) stress response.
It is known, that early development of central nervous system is critically dependent on
child's interaction with the environment (experience dependent maturation), especially to the
attachment to caregivers (most often the mother). Appropriate caregiving is connected to
lower basal cortisol levels in children and a more stable HPA axis response after the
exposure to stress. Any circumstances that disturbed the formation of the attachment to the
primary caregiver (e.g. complications at delivery, psychosocial stressors affecting the
mother or mother's postpartum depression) resulted in higher HPA axis responsiveness to
stress in the affected children.
Changes in individual genes have also been shown to influence a person's susceptibility to
stress and risk for the development of stress-induced psychopathology.
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