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Clinical Trial Summary

The purpose of this study is to investigate the therapeutic effect and safety of Sorafenib in T1DM patients.


Clinical Trial Description

Type 1 Diabetes Mellitus (T1DM) is caused by autoimmune destruction of beta cells in the islet. Insulin has been used as a routine therapy for T1DM to alleviate the hyperglycemic status, yet cannot effectively prevent the progressing destruction of beta cells or preserve its function. Our preliminary data identified sorafenib as an inhibitor of Th1 differentiation and an indirect inhibitor of JAK2 and found that sorafenib prevented and reversed T1DM in NOD mice by decreasing the accumulation of Th1 cells and the expression of inflammatory cytokines in pancreas. Sorafenib is already in clinical use for renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid cancer. It is hypothesized that sorafenib treatment for 26 weeks will preserve beta cell function in adults with new-onset T1DM. The aim of this study is to investigate the potential of sorafenib on preserving beta cell functions in human T1DM. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06227221
Study type Interventional
Source Second Xiangya Hospital of Central South University
Contact
Status Not yet recruiting
Phase Phase 2
Start date June 2024
Completion date December 2026

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