Search for a Link Between the Different Variables for Glycaemia and Oxidative Stress or Impaired HDL Function — Holter Gly  

Type-1 Diabetes Clinical Trial

Official title: Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 Diabetes

Status Completed

Clinical Trial Summary

As glycaemic variability on the one hand and hypoglycaemia on the other are associated with oxidative stress and inflammation, they are likely, in type-1 diabetic patients, to affect the oxidation of lipoproteins and HDL function, by altering their anti-atherogenic properties. The aim of this study is thus to determine, in patients with Type 1 Diabetic (T1D) who will wear a glycaemic Holter for 1 week, the glycaemia parameters (mean glycaemia, duration of hypoglycaemia, duration of hyperglycaemia, mean amplitude of glycaemic excursions) associated with proatherogenic alterations in lipoproteins, in particular: - LDL oxidation - HDL oxidation and alterations of HDL function (anti-inflammatory capacity, antioxidant capacity)

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Diabetes Mellitus, Type 1
• Type-1 Diabetes

• NCT number: NCT02862860
• Study type: Interventional
• Source: Centre Hospitalier Universitaire Dijon
• Status: Completed
• Phase: N/A
• Start date: May 29, 2012
• Completion date: April 17, 2018