Clinical Trials Logo

Clinical Trial Summary

Glioblastoma is the most common adult brain tumour with approximately 2000 new cases each year in the UK.

Optimal treatment consists of surgery followed by radiotherapy and chemotherapy but despite this survival is poor with only 10% of patients alive at 5 years.

Standard imaging (MRI and CT) may not detect the full extent of tumours before treatment and it can be difficult to assess how the tumour is responding to treatment.

The study aims to evaluate more advanced imaging techniques to see if they are better at mapping the whole tumour and assessing response to treatment. Two different imaging techniques will be assessed: Positron Emission Tomography - Computed Tomography (PET-CT) uses a mildly radioactive compound injected into the patient which is taken up into brain tumour cells and shows up as a bright spot on scans. Brain tumours affect blood supply and how much fluid is in the brain tissue as well as how freely fluid can move around. Advanced MR imaging known as multiparametric MRI will be used to look at these additional features. This extra information may help improve planning of radiotherapy and assessing how tumours respond to treatment. Twelve adult patients with glioblastoma undergoing radical treatment will be recruited over a 12 month period. Each patient will have standard MR imaging before radiotherapy (after surgery) and 4-6 weeks following completion of radiotherapy. They will also have advanced MRI and PET/CT before, during and after treatment.

The aim will be to study if this is feasible and could potentially improve radiotherapy planning and response assessment. Imaging will be interpreted by both imaging and brain tumour treatment experts.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03409549
Study type Observational
Source The Leeds Teaching Hospitals NHS Trust
Contact Andrew Scarsbrook, BMedSci BMBS FRCR
Phone 01132068212
Email a.scarsbrook@nhs.net
Status Recruiting
Phase
Start date June 1, 2019
Completion date October 31, 2020

See also
  Status Clinical Trial Phase
Completed NCT03641443 - non_invasive_aICP_Tumor N/A
Recruiting NCT05477680 - Intraoperative Brain Shift Calculation Study N/A
Recruiting NCT05484219 - Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations N/A
Recruiting NCT05484245 - Sonography-guided Resection of Brain Mass Lesions N/A
Withdrawn NCT03177252 - Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients Phase 1
Recruiting NCT04249921 - Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base
Not yet recruiting NCT05777499 - MUSic Therapy In Complex Specialist Neurorehabilitation N/A
Withdrawn NCT04344626 - Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery N/A
Completed NCT00199511 - Hypertonic Saline 75% vs Mannitol 20% N/A
Recruiting NCT05086497 - WBSI Guided Personalized Delivery of TTFields N/A
Recruiting NCT05689112 - Microscopy Imaging of Whole-mount Stained Human Tissues
Recruiting NCT04189172 - MiDura-Study (Neuro-Patch in Duraplasty)
Terminated NCT03471702 - A Secondary Study Evaluating Aqueduct's Smart External Drain (SED) N/A
Recruiting NCT04859543 - Pediatric Prospective Personalized Immune and Target Identification Trial N/A
Recruiting NCT04163315 - Multimodal Connectome Study of Brain Tumor-operated Patients N/A
Completed NCT03503110 - Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation N/A
Completed NCT03113799 - A Study Evaluate Aqueduct's Smart External Drain N/A
Available NCT05974410 - Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients