Clinical Trials Logo

Clinical Trial Summary

The purpose of the study is to assess accuracy, advantages of functional neuronavigation and calculate safe distance from motor areas to brain tumors and vascular malformations in image-guided surgery.


Clinical Trial Description

Functional images (functional magnetic resonance imaging (fMRI), transcranial magnetic stimulation (TMS), tractography) loaded in neuronavigation are called functional navigation. It is usually combined with anatomical data and allows to display eloquent brain areas. Currently there are plenty of studies concerning possibilities of it's use. In our research we plan to confirm this data and to supplement them with calculating a safe distance from motor areas to various mass lesions in preoperative scans where neurological deficits is not likely to appear after surgery. In case of success this data can be a foundation for further researches specifying indications for use of intraoperative neuromonitoring and possibility of it's replacement with functional navigation in some cases. The purpose of the study is to assess accuracy, advantages of functional neuronavigation and calculate safe distance from motor areas to brain tumors and vascular malformations in image-guided surgery. For each patient a surgeon intraoperatively will assess locations of motor cortex and corticospinal tract found with direct cortical and subcortical stimulation and capture them. After surgery he will compare this data with functional preoperative scans and virtual motor centers constructed based on tractography. Influence of various factors on precision of functional navigation will be studied and safe distance between motor brain areas and mass lesion borders will be calculated. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05484219
Study type Interventional
Source Sklifosovsky Institute of Emergency Care
Contact Alexander Dmitriev, MD
Phone +7 (916) 423-54-08
Email dmitriev@neurosklif.ru
Status Recruiting
Phase N/A
Start date September 1, 2022
Completion date August 31, 2027

See also
  Status Clinical Trial Phase
Recruiting NCT03306823 - Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1 N/A
Recruiting NCT03306836 - Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2 N/A
Completed NCT01347307 - Stereotactic Body Radiotherapy for Spine Tumors N/A
Recruiting NCT02042326 - Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Phase 2
Recruiting NCT05484245 - Sonography-guided Resection of Brain Mass Lesions N/A
Recruiting NCT05477680 - Intraoperative Brain Shift Calculation Study N/A
Completed NCT03656211 - Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation
Completed NCT04246125 - Patient Skin Dose in Interventional Radiology
Recruiting NCT02879071 - Long Term Follow-up After Embolization of Brain Arteriovenous Malformations
Terminated NCT01801488 - Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm N/A
Recruiting NCT06259292 - Comprehensive HHT Outcomes Registry of the United States (CHORUS)
Recruiting NCT02098252 - Treatment of Brain AVMs (TOBAS) Study N/A
Completed NCT02378883 - Apollo™ Onyx™ Delivery Microcatheter Post Market Safety Study N/A
Completed NCT00783523 - Influence of MMP on Brain AVM Hemorrhage Phase 1
Recruiting NCT05276934 - Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
Recruiting NCT03031873 - Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations N/A
Withdrawn NCT02079818 - Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Phase 4
Completed NCT01381952 - Image Quality and Radiation Dose in Angiography N/A
Active, not recruiting NCT05418816 - SelfWrap-Assisted Arteriovenous Fistulas N/A
Active, not recruiting NCT03559556 - Treating Arteriovenous Malformation With Stereotactic Radiosurgery Using CT Angiography for Treatment Planning Early Phase 1