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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03851159
Other study ID # N14_10_136
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date May 10, 2019
Est. completion date December 31, 2024

Study information

Verified date March 2024
Source University of Stellenbosch
Contact Grant Theron, PhD
Phone (+27) 21 938 9693
Email gtheron@sun.ac.za
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This will be the first study to evaluate the use of Nyaditum resae® as a potential agent for reducing antibiotic-associated gut dysbiosis in patients with drug-susceptible TB, and potentially improving clinical and microbiological markers of outcome


Description:

About one tenth of the 1.7 billion individuals infected with Mycobacterium tuberculosis (Mtb) will progress to active tuberculosis (TB). This probability increases in people with human immunodeficiency virus (HIV) and other risk co-morbidities such as malnutrition, diabetes and substance abuse. Chronic microbial colonisation with unrelated bacteria are associated with TB pathogenesis (e.g., mice colonised with Helicobacter hepaticus exhibit poor control of TB), indicating that the gut microbiota may modulate progression to active TB. Furthermore, first-line TB treatment (Isoniazid, Rifampicin, Ethambutol, Pyrazinamide; HREZ) depletes gut commensal bacteria (Ruminococcus, Coprococcus and Bifidobacterium) with immunomodulatory roles [interleukin (IL)-1, interferon (IFN)-γ and Th17 responses, respectively). Recent work identified heat-killed Mycobacterium manresensis (hkMm), a harmless member of the fortuitum complex naturally found in drinking water, as a promising candidate for reducing the risk of active TB. Mtb-infected mice treated with hkMm had significantly reduced lung pathology (fewer and smaller lesions,) bacillary load and proinflammatory cytokines (TNF-α, IFN-γ, IL-6, and IL-17) compared to untreated control mice, and in mice receiving hkMm with HREZ, survival rates were significantly increased. Moreover, mice treated with hkMm had increased microbial diversity and an altered gut microbial composition relative to untreated mice. This could prove beneficial for TB patients during prolonged antibiotic treatment as supplementation with hkMm may help protect gut microbiota, and potentially improve clinical outcome. In individuals with and without latent M. tuberculosis infection, two weeks of daily oral doses of Nyaditum resae® (a preparation of hkMm approved as a food supplement by Manremyc) demonstrated enhanced effector and memory specific regulatory T-cell responses. Similar clinical trials with Nyaditum resae® are currently being done in paediatrics (NCT02581579) and close contacts of active TB cases in Tbilisi, Georgia (NCT02897180; 2017-2023). The probiotic is also being registered as a food supplement in several countries. In the proposed study, the efficacy of Nyaditum resae® in reducing antibiotic-associated gut dysbiosis and disease progression in patients with active TB will be tested. To do this, the investigators will assess changes in the microbiota during treatment (with or without Nyaditum resae® supplementation) and attempt to identify genera associated with a favourable or unfavourable treatment outcome in TB patients.


Recruitment information / eligibility

Status Recruiting
Enrollment 48
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: - 18-65 years - New cases - Sputum Xpert Ultra (Xpert) positive for Mycobacterium tuberculosis - Have not initiated TB treatment - If HIV-positive, are stable on antiretroviral therapy Exclusion Criteria: - Resistance to any of the first-line drugs (Xpert rifampicin-resistant) - Previous TB - Diabetes mellitus - Taking immunomodulatory drugs (e.g. cancer chemotherapy, tumour necrosis factor (TNF) inhibitors or other anti-inflammatory medication, phosphodiesterase inhibitors, corticosteroids within the past 6 months, and cholesterol-lowering drugs) - Pregnant or lactating women - Chronic hepatitis

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Nyaditum resae®
Heat-killed Mycobacterium manresensis
Other:
Mannitol
Placebo

Locations

Country Name City State
South Africa Scottsdene Clinic Cape Town Western Cape
South Africa Wallacedene Clinic Cape Town Western Cape

Sponsors (2)

Lead Sponsor Collaborator
University of Stellenbosch Fundació Institut Germans Trias i Pujol

Country where clinical trial is conducted

South Africa, 

Outcome

Type Measure Description Time frame Safety issue
Primary Gut microbiome composition in placebo versus experimental arm Gut microbial composition determined by next-generation sequencing of bacterial DNA in stool Up to 18 months
Secondary Cytokine and cluster of differentiation (CD)4+ T-cell response in placebo versus experimental arm Cytokines responses profiled using commercial human cytokine panel, and T-cell responses characterised by flow cytometry on isolated peripheral blood mononuclear cells Up to 18 months
Secondary Time to sputum conversion and reduction in bacillary load Culture used to assess sputum conversion and bacillary load Up to 6 months
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