Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

Status Recruiting

Clinical Trial Summary

The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived metrics in TBI patients with healthy subjects as well as Subarachnoid hemorrhage (SAH) patients to better understand if metabolic Magnetic resonance imaging scan (MRI) can improve our ability to diagnose a TBI. The FDA is allowing the use of hyperpolarized [1-13C] pyruvate (HP 13C-pyruvate) in this study. Up to 15 patients (5 with TBI, 5 with SAH, and 5 healthy volunteers) may take part in this study at the University of Maryland, Baltimore (UMB).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06103201
Study type	Interventional
Source	University of Maryland, Baltimore
Contact	Rosy Linda Njonkou Tchoquessi
Phone	410-706-0943
Email	rnjonkou@som.umaryland.edu
Status	Recruiting
Phase	Phase 1
Start date	October 26, 2023
Completion date	November 26, 2026

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