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Study on Cerebral Protection of Dexmedetomidine for Patients With Traumatic Brain Injury

Traumatic Brain Injury Clinical Trial

Official title:
Cerebral Protection of Dexmedetomidine Against Paroxysmal Sympathetic Overexcited in Patients With Traumatic Brain Injury

Clinical Trial Summary

The aim of the study is to investigate whether dexmedetomidine could suppress catecholamine release into peripheral blood to prevent PSH attacks and to achieve neuroprotection.

Clinical Trial Description

Paroxysmal sympathetic hyperactivity (PSH) is a syndrome typically recognized in patients suffering from traumatic brain injury, characterized by paroxysmal increases in sympathetic activity such as elevated heart rate, increased blood pressure and respiratory rate, high temperature, excessive sweating and abnormal motor (posturing) activity.

This prospective study will include patients with traumatic brain injury,who will be divided into two groups, evaluated by the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM). Patients will also be evaluated with head CT.

The aim of the study is to investigate whether dexmedetomidine could suppress catecholamine release into peripheral blood to prevent PSH attacks and to achieve neuroprotection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04006054
Study type Interventional
Source Xiangya Hospital of Central South University
Contact Xin Chen, Doctor
Phone 13517315332
Email 21806497@qq.com
Status Recruiting
Phase Phase 4
Start date June 6, 2019
Completion date December 30, 2021
View Details
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